血清化物作为一个呼吸衰竭标志物在肌缩侧面硬化症
Umberto Manera1,2, Maurizio Grassano1, Enrico Matteoni1
1"Rita Levi Montalcini" Department of Neuroscience, University of Turin, Turin, Italy.
Frontiers in aging neuroscience
|June 9, 2023
概括
诊断时的血清化物水平可以预测肌缩侧硬化症 (ALS) 患者的生存和非侵入性通风 (NIV) 需求. 这种低成本的标记物有助于早期识别患有呼吸衰竭风险的患者.
科学领域:
- 神经学 神经学
- 肺部病理学 肺部病理学
- 生物标志物 生物标志物
背景情况:
- 呼吸衰竭是肌缩侧面硬化症 (ALS) 死亡的主要原因.
- 早期识别患有呼吸失补偿风险的患者对于及时进行非侵入性通风干预至关重要.
- 血清化物水平反映了呼吸系统酸性疾病的代谢补偿,是一种易于获得的,低成本的测量方法.
研究的目的:
- 研究诊断时的血清化物值作为ALS患者整体存活时间的预后生物标志物.
- 评估血清化物水平在预测适应ALS非侵入性通风 (NIV) 时的有用性.
- 探索血清化物和其他临床和血清学标记在ALS之间的相关性.
主要方法:
- 来自皮埃蒙特和阿奥斯塔河谷ALS登记册的大量ALS患者队伍的回顾性分析.
- 诊断时血清化物水平的评估,以及临床特征和其他血清生物标志物.
- 时间到事件分析,包括单变量和多变量回归,以建模整体生存率和NIV启动的时间.
主要成果:
- 诊断时的血清化物水平与炎症标志物,血清,强迫生命能力 (FVC),ALSFRS-R评分,年龄和体重减轻有显著的相关性.
- 时间到事件分析证实,血清化物值显著影响了整体存活率和开始NIV的时间,即使经过对混因素进行调整.
- 较低的血清化物水平被确定为预后较差的预测因素,并增加了呼吸失补偿的风险.
结论:
- 诊断时测量的血清化物是一种宝贵的,低成本的预后生物标志物,用于肌缩性侧面硬化症 (ALS).
- 它可以根据患者即将出现呼吸衰竭的风险来分层患者,并指导NIV启动.
- 血清化物应被视为常规预后标记在早期评估的ALS患者.
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