发育中的thalamo-cortical和cerebello-cortical功能连接性
Carolina Badke D'Andrea1,2,3, Scott Marek3, Andrew N Van4,5
1Department of Cognitive Science, University of California San Diego, La Jolla, CA 92093, United States.
Cerebral cortex (New York, N.Y. : 1991)
|June 9, 2023
概括
儿童表现出比成年人更强大的thalamic功能连接,特别是在腹部thalamus和体运动面部网络. 小脑连接性没有显示出发育差异,这表明大脑通路的明显成熟.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 功能神经成像 功能神经成像
背景情况:
- 丘陵体是感觉,运动和认知功能的关键中继器,是皮质-状体-丘陵体-皮质 (CSTC) 和皮质-状体-大脑-丘陵体-皮质 (CPCTC) 途径的组成部分.
- 这些关键神经回路的发育轨迹仍未得到充分研究,特别是在体内使用功能连接MRI.
- 有限的研究存在于发育的变化在thalamo-cortical和cerebello-cortical功能连接.
研究的目的:
- 调查儿童和成人与皮质网络的thalamic和小脑功能连接的发育差异.
- 用静止状态fMRI比较儿童 (7-12岁) 和成年人 (19-40岁) 之间的功能连接模式.
- 阐明在人类发育过程中CSTC和CPCTC途径中的成熟模式.
主要方法:
- 利用休息状态功能连接MRI (rs-fMRI) 来评估大脑网络连接.
- 分析了与预定义的皮质网络的乳头和小脑之间的功能连接.
- 对比了两个不同的数据集的连接数据:儿童 (7-12岁) 和成年人 (19-40岁).
主要成果:
- 与成年人相比,在儿童中发现腹部丘脑和人体运动面部皮质网络之间的功能连接显著更强.
- 观察到儿童的脑皮层网络在丘脑内比成年人更大的整合.
- 在大脑-皮层功能连接方面没有发现显著的发育差异.
结论:
- 结果表明,CSTC和CPCTC途径的发展成熟模式不同.
- 这些发现表明,甲状腺皮层电路的长期发展,特别是涉及腹部甲状腺和体力运动区域的电路.
- 与被调查的乳头皮层电路相比,小脑路径的成熟程度似乎不同或更早.
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