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在多对比血管磁粒子成像中进行放松光谱分析

Xin Feng¹, Guang Jia², Jiaming Peng³

¹CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, China.

Medical physics

|June 9, 2023

概括

这项研究引入了一种新的方法,用于测量磁纳米粒子 (MNPs) 中的尼尔和布朗的放松时间,使用脉冲激发. 这种技术可以在先进的血管成像应用中更好地表征MNP.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
医疗成像医学成像

背景情况:

磁纳米粒子 (MNPs) 是血管,分子和神经成像的关键非电离型标记物.
了解尼尔 (内部) 和布朗 (外部) 放松机制是MNP特征的关键.
精确测量放松时间有助于预测MNP类型和水力动态状态.
在MPI中,常规的阴侧刺激难以区分尼尔和布朗的放松组件.

研究的目的:

开发一种多指数放松光谱分析方法,用于独立测量尼尔和布朗的放松时间.
将这种方法应用于脉冲血管磁粒子成像 (MPI) 中的磁化恢复.

主要方法:

在带有不同粘度的Synomag-D样本的梯形波形放松计中利用脉冲刺激.
在放松衰变信号上采用基于拉普拉斯变换的反向光谱分析 (PDCO方法).
研究样本具有不同的甘油和凝度,以分离放松时间.
模拟数字血管幻影的光谱成像与粘性和固定MNP.

主要成果:

在具有不同粘度的样本中确定了明显的尼尔和布朗的放松时间峰值.
观察到布朗松时间和粘度 (0.93.2 mPa·s) 之间的正线性相关性,和度超过3.2 mPa·s.
发现Néel放松时间随着粘度略有减少,也显示和度.
在模拟的布朗式放松时间图中,证明了斑块,导管和血管区域的分化.
确定布朗式放松时间灵敏度的最佳场幅约为4.5mT.

结论:

通过脉冲刺激的光谱分析,成功量化了尼尔和布朗的放松时间.
开发的方法可以在血管MPI中进行多对比成像.
这种定量评估对基于MNP的先进成像技术具有重大潜力.

关键词:

磁性纳米粒子是一种磁性纳米粒子.磁性颗粒成像技术磁性粒子成像技术放松时间,放松时间.粘度映射绘制粘度映射绘制

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