通过肠道淋巴管进行自我微乳化药物输送:一种有利可图的药物向药物向方法
Darshan Petkar Ramachandra1, Preethi Sudheer1
1Department of Pharmaceutics, Krupanidhi College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka, India.
Pharmaceutical nanotechnology
|June 9, 2023
概括
肠道淋巴细胞增强了脂性药物的吸收. 自行微乳化药物递送系统 (SMEDDS) 通过提高溶解度和生物可用性来改善口服药物递送.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药物输送系统 药物输送系统
- 胃肠病学 胃肠病学
背景情况:
- 肠道淋巴管是吸收脂性物质的专用途径,提供诸如绕过第一通代谢和增强生物可用性等优势.
- 难溶性水友性药物的口服药物输送面临着可以通过先进的配方策略克服的挑战.
- 自微乳化药物递送系统 (SMEDDS) 是一种有希望的基于脂质的方法,可以提高药物的溶解性和生物可用性.
结论:
- 在改善口服药物输送方面,SMEDDS具有显著的潜力,特别是对于脂性药物.
- 对淋巴细胞向和SMEDDS配方的进一步研究可以导致更有效的疗法.
- 审查强调了这些系统在现代制药发展中的重要性.
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