量化生物过程的水力动力应力
Umut Kaya1,2, Srikanth Gopireddy1,2, Nora Urbanetz1
1Supply Chain Operations, Pharmaceutical Development, Daiichi Sankyo Europe GmbH, Pfaffenhofen, Germany.
Biotechnology progress
|June 9, 2023
概括
存在不同的方法来计算生物过程中的水力动力应力. 这项研究建议使用主要应力值来更清楚地区分剪切和正常组件,显示生物反应器模拟中的显著差异.
科学领域:
- 生物物理学的生物物理.
- 流体动力学 流体动力学
- 生物化学工程 生物化学工程
背景情况:
- 水力动力压力显著影响生物过程,影响细胞的性能和活力.
- 目前用于从速度场计算水力动力应力元件 (正常和剪切) 的方法缺乏共识.
- 这种变异性阻碍了对生物系统中物理参数效应的一致解释.
研究的目的:
- 研究和定义各种方法来计算来自速度场的水力动力应力.
- 提出一种新的方法,使用主要应力来最大限度地区分正常和剪切元件.
- 在和的生物反应器模拟中,从数值上比较现有和拟议的方法.
主要方法:
- 审查和清晰定义不同的水力动力应力计算方法.
- 基于主要压力分析的建议方法的开发.
- 计算流体动力学 (CFD) 模拟一个和的生物反应器.
主要成果:
- 证明不同的水力动力应力计算方法可以产生显著不同的结果.
- 确定在特定生物反应器条件下同等的方法.
- 强调主要应力方法在应力组件之间提供最大区分的能力.
结论:
- 计算水力动力应力的方法的选择至关重要,并且可以影响生物过程结果的解释.
- 主要应力分析为区分正常和剪切应力组件提供了更具代表性的措施.
- 方法等价性取决于条件,需要仔细选择以进行准确的生物过程分析.
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