姆波克斯生殖器损伤:一个大型单中心的经验与中间的随访
Justin Lee1, Jacob McLean2, Jason Zucker2
1Department of Urology, Columbia University Irving Medical Center, New York, New York.
The Journal of urology
|June 9, 2023
概括
常见的是Mopox (以前称为病毒) 的生殖器病变. 德科维里马特治疗表明,严重的阴茎皮肤变化与病变大小有关,大多数患者避免手术.
科学领域:
- 病毒学 病毒学
- 皮肤病学 皮肤病学
- 传染性疾病 传染性疾病
背景情况:
- 全球爆发的Mpox (原名麻疹病毒) 疫情凸显了了解生殖器损伤管理的必要性.
- 生殖器损伤影响近50%的Mpox感染患者,需要临床数据.
- 关于Mpox相关的生殖器表现的临床过程和治疗的报道有限.
研究的目的:
- 描述一大群患有生殖器Mpox病变的患者的临床表现,治疗方法和结果.
- 为了评估tecovirimat治疗在这个患者群体中的有效性.
- 为了确定与严重的生殖器皮肤变化相关的因素,在Mpox患者.
主要方法:
- 追溯68名患有生殖器Mpox病变的患者的病例系列,他们接受了tecovirimat治疗.
- 根据CDC紧急授权调查协议收集的数据.
- 费舍尔的精确测试用于分析生殖器皮肤变化和分类变量之间的关联.
主要成果:
- 参与者的平均年龄为34.9岁;所有参与者在出生时都被分配了男性性别.
- 平均随访时间为20.3天;治疗包括支持性护理和抗生素治疗超级感染.
- 16名患者 (23.5%) 患有阴茎皮肤显著变化,与病变大小相关 (P = .001);不需要进行手术干预.
结论:
- 这项研究呈现了一系列与Mpox相关的大量男性的生殖器病变,这些男性接受了tecovirimat治疗.
- 泌尿科医生的咨询通常不需要,但对于严重的病例来说是有价值的.
- 德科维里马似乎是一个可行的治疗选择,病变大小是严重程度的关键预测指标.
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