轻微的SARS-CoV-2感染导致长期的微生物群不稳定
Vaibhav Upadhyay1,2,3, Rahul K Suryawanshi4, Preston Tasoff3
1Department of Microbiology and Immunology, G.W. Hooper Research Foundation, University of California , San Francisco, California, USA.
mBio
|June 9, 2023
概括
即使是轻微的SARS-CoV-2感染病例也会破坏肠道微生物群,导致长期的不稳定. 这种效应在非住院患者中观察到,并在各种SARS-CoV-2变异的小鼠模型中得到证实.
科学领域:
- 微生物学 微生物学
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染与住院患者的肠道微生物群破坏有关.
- 轻度SARS-CoV-2对门诊患者肠道微生物群的影响在很大程度上是未知的.
- 肠道疾病可以加剧病毒性疾病的表型.
研究的目的:
- 为了研究轻度SARS-CoV-2感染在门诊环境中对肠道微生物群的纵向影响.
- 为了比较SARS-CoV-2-阳性门诊患者和家庭对照者之间的肠道微生物群稳定性.
- 为了验证敏感小鼠模型中的发现,并评估不同SARS-CoV-2变体的影响.
主要方法:
- 14名SARS-CoV-2-阳性门诊患者和4名家庭对照者的纵向采样.
- 对肠道微生物生态和稳定性的分析.
- 感染K18-人性化的血管酶转化酶2 (ACE2) 和野生型C57BL/6J小鼠的SARS-CoV-2变体 (美国-WA1/2020,三角洲,奥米克朗).
- 感染小鼠肺部病理的评估.
主要成果:
- 与对照组相比,SARS-CoV-2-阳性门诊患者的肠道微生物群显著不太稳定.
- 所有测试的SARS-CoV-2变种都破坏了小鼠的肠道微生物群.
- 尽管Omicron变种引起了较轻微的症状,但它显著削弱了Akkermansia muciniphila.
- 肠道微生物群的破坏发生在小鼠中,即使没有严重的肺病理.
结论:
- 轻微的SARS-CoV-2感染可以导致长期的肠道微生物不稳定.
- 肠道微生物群受到SARS-CoV-2的干扰,在包括Omicron在内的各个变种中都保持不变.
- 需要进一步的研究,以了解SARS-CoV-2-诱导的肠道失生症对宿主健康的机制和后果.
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