前列腺瘤微环境的景观和相关治疗点的进展
Duocai Li1, Weidong Xu1, Yifan Chang2
1Department of Urology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.
Acta biochimica et biophysica Sinica
|June 9, 2023
概括
本综述详细介绍了前列腺癌瘤微环境 (TME),其组成部分及其在癌症进展中的作用. 它还总结了前列腺癌 (PCa) 的TME向治疗方法.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 免疫学 免疫学 免疫学
背景情况:
- 前列腺瘤微环境 (TME) 是一个复杂的系统,包括结构细胞,免疫细胞和细胞外基质 (ECM).
- PCa TME的关键特征包括免疫抑制,酸性和缺氧,神经元内化和促进瘤生长和转移的代谢变化.
- 了解三级淋巴体结构 (TLS) 和转移,可以提高对前列腺癌 (PCa) 转移的理解.
结论:
- 对PCa TME的全面理解对于开发有效的癌症疗法至关重要.
- 针对TME提供了对前列腺癌新型治疗策略的有希望的途径.
- 目前正在进行的研究和临床试验正在评估TME导向治疗PCa的疗效.
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