肠道细菌和结直肠癌中的性别差异
Xi Yang1,2,3, Ping Li2, Zhanbo Qu1,4
1Huzhou Central Hospital, Affiliated Central Hospital HuZhou University, Zhejiang, PR China.
Journal of medical microbiology
|June 9, 2023
概括
肠道细菌的组成在结肠直肠癌 (CRC) 患者的性别之间存在差异. 了解这些差异对于个性化CRC查和治疗策略至关重要.
科学领域:
- 微生物组研究的研究.
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 肠道微生物组成的性别差异与结直肠癌 (CRC) 发病率有关.
- 男人呈现较高的CRC发病率,但缺乏关于CRC患者性别特异性肠道细菌的临床数据.
研究的目的:
- 在被诊断为结直肠癌的患者中调查肠道细菌组成和性别之间的关系.
- 识别特定的肠道细菌,这些细菌在患有CRC的男性和女性之间存在显著差异.
主要方法:
- 来自6077名患者样本的肠道微生物组合的分析.
- 使用线性差异分析效果大小 (LEfSe) 来识别差异性细菌.
- 采用皮尔森相关性和CRC风险预测模型来评估细菌的重要性.
主要成果:
- 在男性 (Bacteroides, Eubacterium, Faecalibacterium) 和女性 (Bacteroides, Subdoligranulum, Eubacterium) 患有CRC时,确定了三种不同的肠道细菌系.
- 在患有CRC的男性中观察到某些肠道细菌 (例如,Escherichia,Eubacteriales) 的较高丰度.
- 在CRC患者中,蓝菌,巴尼塞拉菌和无气型菌被确定为性别歧视的关键细菌,预测模型达到83.3%的准确性.
结论:
- 在结直肠癌患者中,肠道微生物群的组成与性别有显著的相关性.
- 性别特定的肠道细菌概况有可能改善CRC预测,并指导个性化的治疗方法.
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