温度诱导的纳米结构转换为水中的超分子化
Rajan Deepan Chakravarthy1, Imam Sahroni1,2, Chen-Wen Wang1
1Department of Materials Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu 300093, Taiwan, Republic of China.
ACS nano
|June 9, 2023
概括
研究人员使用温度诱导纳米结构转换 (TINT) 系统开发了一种新的可注射水凝. 这种生物材料提供了增强的刚性,并支持干细胞粘附,推进组织工程应用.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 组织工程是组织工程.
背景情况:
- 可注射的热凝由于刚度低而受到限制,阻碍了诸如干细胞研究等生物医学应用.
- 化学交联的双网 (DN) 水凝提供了刚性,但缺乏可注射性和热敏性.
研究的目的:
- 开发一种物理交叉连接的超分子水凝,具有增强的刚性,可注射性和热敏性.
- 为了创建一个新的温度诱导纳米结构过渡 (TINT) 系统用于水凝制备.
主要方法:
- 芳香 (Ben-FF) 和聚乙烯甘醇 (PEG) 的联合组装,形成转移稳定的纳米纤维.
- 采用了基于纳米纤维解离和随后由热扰动引发的水凝的自下而上的策略.
- 描述了水凝的特性,包括储存模量 (G') 与温度的变化以及评估的细胞毒性.
主要成果:
- 在TINT系统生产可注射,热可逆物理DN超分子凝.
- 储存模量 (G') 从20°C增加了大约14倍,达到37°C (体温).
- 水凝对人间介质干细胞没有毒性,并且增强了细胞粘附.
结论:
- 在TINT系统成功地创建了刚性,可注射和热敏超分子水凝.
- 该战略为开发用于组织工程和再生医学的先进生物材料提供了有前途的方法.
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