母亲分离及其对焦虑和杏仁体内蛋白内神经元的发展后果
Mate Abraham1, Kirsten Schmerder1, Malin Hedtstück1
1Division of Experimental and Molecular Psychiatry, Department of Psychiatry, Psychotherapy and Preventive Medicine, LWL University Hospital, Ruhr-University Bochum, Universitätsstraße 150, 44780, Bochum, Germany.
概括
早期的生活压力,如母亲的分离,可以导致长期的焦虑行为和杏仁体中帕瓦胺阳性内部神经元的变化,其影响因发育阶段而异.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 早期产后压力是神经发育变化的关键时期.
- 在海马体和杏仁体中改变GABAergic活性与焦虑和抑郁有关.
- 帕尔瓦胺 (PV) 表达和周围神经网络完整性反映了GABAergic变化.
研究的目的:
- 调查母亲分离 (MS) 对焦虑行为和杏仁体帕瓦白蛋白 (PV+) 内神经元的长期影响.
- 为了检查对早期生活压力的反应中的性别差异.
- 探索压力诱导的行为和神经生物学变化的发展轨迹.
主要方法:
- 斯普拉格-道利大鼠的母体分离 (MS) 模型 (每天4小时,产后2-20天).
- 在青春期和成年期的行为测试 (大理石埋葬,升高加迷宫).
- 免疫组织化学分析杏仁体中帕瓦胺 (PV) 阳性内部神经元.
主要成果:
- 多发性硬化症在青春期和成年期都引起了增加的焦虑行为.
- 在MS后的青春期观察到,杏仁体内减少PV+内神经元的趋势.
- 在行为或神经生物学结果中没有发现任何显著的性别差异.
- 随着时间的推移,焦虑行为从积极的回避转变为被动的回避.
结论:
- 早期的生活压力对行为和神经生物学有持久的影响.
- 发育阶段对压力效应的表现有很大影响.
- 多发性硬化可能导致杏仁体电路中细胞类型特定的变化.
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