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开发和验证差异化甲状腺癌与远程转移的患者的生存名录:基于SEER计划的研究

Q Ma¹, Z Chen¹, Y Fang¹

¹Department of Endocrinology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.

Journal of endocrinological investigation

|June 9, 2023

概括

我们开发了差异化甲状腺癌与远程转移的预后诺姆图. 这些模型准确地预测了整体生存率和癌症特异性生存率,超过了AJCC8SS分期系统.

科学领域:

在瘤学瘤学.
医学统计医学统计
癌症预后癌症预后

背景情况:

远程转移性差异化甲状腺癌 (DMDTC) 需要准确的预后工具.
现有的分期系统可能无法完全捕捉DMDTC中的生存细微差别.

研究的目的:

开发和验证DMDTC患者的整体生存期 (OS) 和癌症特异性生存期 (CSS) 的诺米克模型.
为了比较开发的诺姆图的预后性能与美国癌症瘤结节转移阶段系统联合委员会 (AJCC8SS) 的第八版.

主要方法:

利用来自SEER计划的906名DMDTC患者 (2004-2015) 的数据.
采用LASSO和多变量考克斯回归来识别OS和CSS名录的预测因子.
使用C指数,ROC曲线,校准图表和决策曲线分析 (DCA) 验证的诺姆图.

主要成果:

开发了纳米图,包括年龄,婚姻状况,手术类型,淋巴切除术,放射治疗和T阶段.
实现了高预测准确度,OS的C指数为0.7474,CSS的C指数为0.7572.
与AJCC8SS相比,Nomograms显示出更高的准确性和预测能力,DCA显示出良好的校准和临床实用性.

结论:

确立并验证了DMDTC患者的预后诺姆图.
与AJCC8SS.SS相比,开发的诺摩图提供了显著的临床价值和更好的预后准确性.

关键词:

有差异化的甲状腺癌.远程转移是发生在远程转移的.这个名字叫做Nomogram.在 SEER 计划中,幸存的生存方式

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