韩国艾滋病毒感染患者的发作与渐进的多焦点白血脑病相关
Hyun Kyung Kim1, Ji Yun Kang1, Seo-Young Lee2
1Department of Neurology, National Medical Center, Seoul, Korea.
Journal of neurovirology
|June 9, 2023
概括
患有进展性多焦点白内障病 (PML) 的艾滋病毒感染患者患风险很高. 认知障碍和MRI上广泛的脑损伤增加了这种风险,即使是在晚期的疾病阶段.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 渐进性多焦点白内障 (PML) 是一种罕见的,影响中枢神经系统的脱髓化疾病.
- 在免疫功能低下的个体中,PML通常与机会性感染有关,特别是那些患有人类免疫缺陷病毒 (HIV) 的人.
- 发作是PML的一种潜在的神经并发症,但它们在特定人群中的发病率和风险因素需要进一步调查.
研究的目的:
- 确定韩国患有与艾滋病毒相关的PML的患者中发作的发生率.
- 确定与本患者队列中发作的临床和放射性风险因素.
- 了解PML诊断和发作之间的时间关系.
主要方法:
- 对34名被诊断患有艾滋病毒相关PML的韩国患者进行了回顾性分析.
- 数据收集包括患者人口统计,临床病史,神经学检查和脑磁共振成像 (MRI) 发现.
- 进行了统计分析,以确定与发作发生相关的因素.
主要成果:
- 34名患者中有14名 (41.2%) 在平均82个月的随访期间发生发作.
- 从PML诊断到发作的中位时间为44个月 (范围:0-133个月).
- 发作与认知障碍和MRI上多个或扩散的大脑病变的存在显著相关.
结论:
- 患有PML的HIV感染患者表现出大量发作发病的风险.
- 认知障碍和MRI上广泛/扩散的大脑病变是增加发作风险的关键指标.
- 这强调了在HIV感染个体的PML整个过程中对发作进行监测的重要性,无论疾病的阶段如何.
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