抗皮素耐药性和易受万科米辛的影响
Daniel Echeverria-Esnal1,2, Luisa Sorli2,3,4, María Eugenia Navarrete-Rouco1
1Department of Pharmacy, Hospital Del Mar, Parc de Salut Mar, Barcelona, Spain.
Expert review of anti-infective therapy
|June 9, 2023
概括
抗白素和易受菌素的Enterococcus faecium (EfARSV) 细菌病正在增加,死亡率很高. 这种难以治疗的感染的最佳治疗方法尚不清楚,需要进一步研究.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 临床药房 临床药房
背景情况:
- 菌 (Enterococcus faecium) 是一种常见的细菌,可以引起严重的感染,如细菌血症.
- 抗白素和易受菌素感染的E. faecium (EfARSV) 菌病是日益令人担忧的,死亡率很高.
- 对于EfARSV细菌病的最佳治疗策略尚未确立.
研究的目的:
- 审查EfARSV细菌病的关键方面.
- 讨论当前的治疗选择及其局限性.
- 为了突出进一步研究的需要.
主要方法:
- 在PubMed.com上进行全面的文献搜索.
- 包括2022年11月15日之前发表的研究.
- 审查的重点是微生物学,耐药性,流行病学和治疗.
主要成果:
- EfARSV细菌病与高死亡率有关,尽管因果关系仍有争议.
- 由于其耐药性模式,EfARSV是一种难以治疗的病原体.
- 葡萄糖,线化物和达普托是治疗选择,但达普托的使用是有争议的.
结论:
- 尽管发生率和死亡率增加,EfARSV细菌病需要更严格的研究.
- 目前关于治疗的临床证据有限,并且存在重大局限性.
- 进一步的精心设计的研究对于指导有效的治疗策略至关重要.
关键词:
细菌病是什么意思 细菌病是什么意思肠球菌 (Enterococcus faecium) 是一个有毒的菌株.血流感染 感染 感染达普米辛是一种菌素.在线zolidlid是什么意思或被认为是黄.泰科普拉尼尼 泰科普拉尼尼这就是Vancomycin.更多相关视频
相关概念视频
Development of Antibiotic Resistance
50
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
50
Antibiotic Selection
54.8K
Overview
54.8K
Bacterial Cell Wall
76
The bacterial cell wall is an essential structural component that encases the plasma membrane, preserving cellular integrity, determining shape, and protecting against osmotic stress. This rigid yet flexible structure primarily comprises peptidoglycan, a polymer that forms a mesh-like matrix conferring mechanical strength and flexibility.Peptidoglycan Composition and StructurePeptidoglycan, the core of the bacterial cell wall, comprises alternating units of N-acetylglucosamine (NAG) and...
76
Antimicrobial Effectiveness
98
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
98
Antimicrobial Proteins
1.1K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
1.1K


