在Candida spp. 在人类肠道健康和疾病:不仅仅是肠道感觉
Irini A M Kreulen1, Wouter J de Jonge1,2,3, René M van den Wijngaard1,2
1Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam UMC, Location Academic Medical Center, Meibergdreef 69-71, 1105 BK, Amsterdam, the Netherlands.
Mycopathologia
|June 9, 2023
概括
肠道微生物组包括像Candida这样的真菌,这些真菌可能与肠道疾病有关. 研究正在扩大Candida的研究范围.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 菌构成了肠道微生物组的0.1-1%.
- 坎迪达菌种是大量的肠道真菌.
- 改变的真菌成分与IBD和IBS等肠道疾病有关.
研究的目的:
- 审查关于肠道Candida殖民和疾病的数据.
- 概述研究肠道真菌的生物和技术挑战.
- 为了突出Candida albicans菌株变异的作用.
主要方法:
- 文化依赖的技术. 文化依赖的技术.
- 基因组元编码技术.基因组元编码技术.
- 对现有数据的文献综述.
主要成果:
- 有证据表明Candida spp.与这种病菌有联系. 肠道疾病的发病率越来越高.
- 在Candida spp. 常常在肠道中大量存在.
- 在Candida albicans中亚种菌株变异是一个新的研究领域.
结论:
- 在Candida spp. 可能在儿科和成人肠道疾病中发挥作用.
- 需要进一步的研究来克服技术和生物方面的挑战.
- 了解涉及Candida的宿主微生物相互作用至关重要.
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