叶变动与斑点的高度持久性和视觉敏度恶化在视网膜静脉封闭中有关
Alessandro Arrigo1, Emanuela Aragona2, Alessio Antropoli2
1Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, via Olgettina 60, 20132, Milan, Italy. alessandro.arrigo@hotmail.com.
Ophthalmology and therapy
|June 9, 2023
概括
叶变形 (FE) 是视网膜静脉封闭 (RVO) 的负预后生物标志物,表明持续的黄斑胀和更糟糕的视觉结果. 光学连贯断层扫描 (OCT) 上的不同FE模式与疾病严重程度相关.
科学领域:
- 眼科医生 眼科 眼科
- 医疗成像医学成像
- 视网膜疾病 视网膜疾病
背景情况:
- 叶变 (FE) 是一种新的光学连贯性断层扫描 (OCT) 发现,与糖尿病黄斑胀的预后不佳有关.
- 这项研究调查了FE在视网膜静脉封闭 (RVO) 的诊断效用.
研究的目的:
- 评价叶变动 (FE) 作为预后生物标志物在中枢视网膜静脉封闭 (CRVO) 和分支视网膜静脉封闭 (BRVO) 中的作用.
主要方法:
- 追溯观察案例系列包括168个CRVO和116个BRVO眼睛与斑点.
- 结构性OCT被用来将FE分为1a,1b和2的模式.
- 临床和成像数据在基线,一年和最后的随访 (平均36-40个月) 时被分析.
主要成果:
- 在38%的CRVO和22%的BRVO眼睛中存在FE,经常在随访期间发展.
- 在CRVO和BRVO中,FE的存在与持续的黄斑胀和更差的视觉结果有显著的相关性.
- FE模式2与最严重的结果相关,包括明显的最佳校正视敏度 (BCVA) 恶化.
结论:
- 叶变形 (FE) 作为RVO的负预后生物标志物,预测持续的黄斑胀和较差的视觉预后.
- 穆勒细胞功能障碍被假设为潜在的机制,影响黄斑支和流体调节.
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