维塔尼亚·维塔尼亚 (Withania Withania) 是一个
Rokaya E Maarouf1, Khaled Shaaban Azab1, Neama M El Fatih1
1Radiation Biology Department, Radiation Research Division, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt.
Human & experimental toxicology
|June 9, 2023
概括
维坦尼亚·索尼费拉 (Ashwagandha) 增强了乳腺癌细胞的亡,无论单独还是与放射治疗相结合. 这种天然产品通过影响关键细胞死亡途径来表现出抗增殖作用.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 细胞生物学 细胞生物学
背景情况:
- 自然产品为癌症治疗提供了潜在的潜力,并减少了副作用.
- 维他尼亚·索姆尼费拉 (Ashwagandha) 是因为其抗癌性质而被探索的.
- 了解其在亡和信号通路中的作用至关重要.
研究的目的:
- 评估Withania somnifera (WS) 在照射乳腺癌细胞 (MCF7和MDA-MB-231) 中诱导亡中的作用.
- 研究SIRT1-BCL2/Bax信号通路在WS诱导的亡中的参与.
- 评估WS和玛辐射对癌细胞死亡的联合作用.
主要方法:
- 乳腺癌系MCF7和MDA-MB-231的细胞培养.
- 治疗组包括对照组,单独使用WS,单独使用马辐射 (4 Gy),以及WS+马辐射.
- 进行了流细胞计 (Annexin V,细胞周期分析) 和基因表达分析 (SIRT1,BCL2,Bax).
主要成果:
- 维坦尼亚·索尼费拉 (Withania somnifera,简称WS) 显示出两种细胞系的确定IC50值的抗增殖作用.
- 在MDA-MB-231和MCF7细胞的特定阶段 (pre-G,G2/M,pre-G1) 中,WS诱导了细胞亡和细胞循环停止.
- 联合WS和辐射治疗显著上调SIRT1和BCL2,同时降低BAX表达.
结论:
- 维坦尼亚·索尼费拉 (WS) 对MDA-MB-231和MCF7乳腺癌细胞表现出抗增殖活性.
- WS增强了亡,可能是通过SIRT1-BCL2/Bax通路的调节.
- WS和放射治疗的结合可能为癌症治疗提供一种协同方法.
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