在临床前的阿尔茨海默病中,纵向血液生物标志物轨迹
Yara Yakoub1, Nicholas J Ashton2,3,4,5, Cherie Strikwerda-Brown1
1Douglas Mental Health University Institute, Centre for Studies on the Prevention of Alzheimer's Disease (StoP-AD), Montreal, Quebec, Canada.
概括
像pTau181和GFAP这样的等离子体生物标志物可以在症状出现前几年跟踪阿尔茨海默病的进展. 这些变化受到遗传学,年龄和性别的影响,为临床前阿尔茨海默病提供了见解.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物发现发现
- 老年学是一门学科.
背景情况:
- 阿尔茨海默病 (AD) 诊断往往发生迟,限制了早期干预的有效性.
- 血生物标志物显示出在临床表现之前几年检测AD病理的潜力.
- 了解这些标记物的纵向变化对于早期AD检测和管理至关重要.
研究的目的:
- 研究与阿尔茨海默病 (AD) 风险相关的血生物标志物的纵向变化.
- 探索遗传 (APOE ε4) 和人口因素对生物标志物轨迹的影响.
- 为了将血生物标志物变化与粉样β (Aβ) 和定子发射断层扫描 (PET) 结果相关联.
主要方法:
- 血Aβ42/40比率的纵向测量,pTau181,pTau231,NfL和GFAP在373名风险较大的老年人中超过4年.
- 分析基因 (APOE ε4) 和人口 (年龄,性别) 因素作为修饰因素.
- 使用Aβ和tauPET扫描来验证发现的子组分析 (n=229).
主要成果:
- 血Aβ42/40比率下降,而NfL和GFAP在纵向上升.
- 携带APOE ε4的携带者表现出血pTau181.1.的较快增加.
- 女人表现出更快的血GFAP增加,和老年人在血NfL.
- 呈阳性Aβ和tauPET扫描的个体表现出血pTau181和GFAP的加速增加.
结论:
- 血pTau181和GFAP水平显示在AD临床前阶段可以检测到的纵向变化.
- 生物标志物进展受到APOE ε4状态,性别和年龄的影响.
- 这些发现支持使用血生物标志物来监测AD进展和早期检测.
更多相关视频
12:28Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
17.4K
07:08A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
Published on: October 20, 2016
7.9K
相关概念视频
01:26Alzheimer's Disease: Overview
536
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
536
01:26Longitudinal Studies
191
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
191
02:20Longitudinal Research
12.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.0K
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
205
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
205