人类副腎皮質的膠囊區域 (zona glomerulosa) 中的粉絲圈結構
Yumin Zhu1, Xuefeng Zhang1,2, Changlong Hu1,2
1School of Life Sciences, Fudan University, Shanghai, China.
Journal of anatomy
|June 9, 2023
概括
人类上腺区域球蛋白 (ZG) 细胞形成状结构,对阿尔多素的产生至关重要. 产生阿尔多的细胞群 (APCC) 也表现出这种状结构,这表明它在激素调节中的重要性.
科学领域:
- 内分泌学 在内分泌学.
- 细胞生物学 细胞生物学
- 历史学 历史学 历史学
背景情况:
- 上腺区域球体 (ZG) 的多细胞状结构对于小鼠的阿尔多激素生产至关重要.
- 人类ZG的状结构及其在阿尔多生成细胞集群 (APCC) 中的作用仍然不清楚.
- 人类上腺皮层随着年龄的增长而重塑,导致APCC的形成.
研究的目的:
- 为了研究人类ZG在上腺体中带有和没有APCC的迷状结构.
- 为了比较正常ZG和APCC的细胞组织.
- 为了确定APCC是否形成类似于正常ZG.的状结构.
主要方法:
- 人类上腺腺体的组织学检查.
- 免疫光染色用于拉米因子单元β1 (lamb1),β-catenin和F-actin的染色.
- 在正常的ZG和APCC中,质体内的细胞计数.
主要成果:
- 人类的ZG球体被一个富含lamb1的底层膜包围.
- 正常的人类ZG含有大约10-11个细胞每粒球体.
- 通过增强的粘附连接,APCC 具有每粒细胞显著更多的细胞 (平均22个) 并通过增强的粘附连接形成更大的红.
结论:
- 人类ZG细胞和APCC细胞通过β-catenin和富含F-actin的粘附结形成了迷状结构.
- APCCs是有组织的结构,而不是随机的细胞群,具有增强的形形成.
- 多细胞罗塞特结构可能对正常的ZG和APCC中阿尔多激素的产生至关重要.
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