通过脉冲波速度和心血管风险分层增强指数测试抗脂综合征中的动脉硬性
Gerasimos Evangelatos1,2, George Konstantonis1, Nikolaos Tentolouris1
1First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Rheumatology (Oxford, England)
|June 9, 2023
概括
与健康个体相比,抗脂综合征 (APS) 患者的动脉硬性增加,特别是增强指数增加. 这种动脉硬化是心血管风险因素,突显了需要在APS患者中进行更密切的监测.
科学领域:
- 心血管医学 心血管医学
- 类风湿病学 类风湿病学
- 血管生物学 血管生物学
背景情况:
- 抗脂综合征 (APS) 是导致心血管疾病和死亡的一个重要原因.
- 动脉硬 (ArS) 是一般人群中心血管事件的公认预测因素.
研究的目的:
- 在患有血栓性抗脂综合征 (APS) 的患者中评估动脉硬 (ArS).
- 将APS患者的ARS与糖尿病患者 (DM) 和健康对照者 (HC) 的ARS进行比较.
- 在APS队列中确定增加ARS的预测因素.
主要方法:
- 动脉硬度是通过心脏 - 骨脉冲波速率 (cfPWV) 和增强指数 (AIx@75) 来评估的.
- 动脉和股骨超声波进行检测动脉样硬化斑块.
- 使用线性回归模型来比较ARS测量,并确定APS患者的决定因素.
主要成果:
- 与HC相比,APS患者的AIx@75显着更高,表明动脉硬化增强.
- 虽然cfPWV在APS和HC之间类似,但APS患者的cfPWV比DM患者低.
- 在APS中增加cfPWV的独立预测因素包括年龄,平均动脉压 (MAP),大腿动脉样硬化斑块和抗β2-糖蛋白I IgM阳性.
结论:
- 在APS患者中,AIx@75升高,表明动脉硬化增加.
- 动脉硬度评估可以改善APS患者的心血管风险分层.
- 这些发现强调了评估ARS在APS患者心血管风险管理中的重要性.
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