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超宽带宽高分辨率全光学血管内超声波,使用小型光声传感器

Lei Wang¹, Yongwen Zhao¹, Bo Zheng²

¹Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Institute of Medical Photonics, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.

Science advances

|June 9, 2023

概括

一个全光学血管内超声波 (AO-IVUS) 系统实现了超宽带宽和高分辨率,用于详细的血管成像. 这种新的技术超越了传统方法,为临床应用提供了显著的潜力.

科学领域:

生物医学光学生物医学光学
医疗成像医学成像
超声波技术超声波技术

背景情况:

传统的血管内超声波 (IVUS) 在没有影响成像深度的情况下同时实现高分辨率和宽带宽方面存在局限性.
传统IVUS中的压电传感器限制了性能改进.

研究的目的:

开发和描述一个全光学IVUS (AO-IVUS) 成像系统.
为了克服传统IVUS的分辨率和带宽限制.
在临床前模型中评估AO-IVUS在详细血管成像方面的潜力.

主要方法:

使用皮秒激光脉冲碳复合材料用于超声波激发.
用于超声波检测的π相位移纤维布拉格格.
在幻影和临床前动物模型 (子和猪动脉) 中进行成像,包括那些带有药物释放支架的人,与商业IVUS进行比较.

主要成果:

实现了超宽带宽 (147%) 和高轴分辨率 (18.6微米).
展示了124微米的横向分辨率和7毫米的成像深度.
在血管结构中,AO-IVUS成功地描绘了细节,在分辨率方面超过了传统的IVUS.

结论:

与传统技术相比,开发的AO-IVUS系统提供了卓越的成像性能.
高分辨率成像能力突显了AO-IVUS在改善临床诊断和干预方面的潜力.
这种全光学方法代表了血管内成像技术的重大进步.

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