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在撒哈拉以南非洲艾滋病毒感染者中绘制密码球菌抗原感染的证据 - - 一个范围审查协议

Khululiwe Dlamini¹, Boitumelo Moetlhoa¹, Astrid Turner¹

¹School of Health Systems and Public Health, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

|June 9, 2023

概括

加密球菌抗原感染是撒哈拉以南非洲艾滋病毒感染者的主要死亡原因. 本综述绘制了证据,以指导未来的研究和干预措施,以改善管理.

科学领域:

传染性疾病传染性疾病
公共卫生公共卫生
艾滋病毒/艾滋病研究研究

背景情况:

中枢神经系统感染是艾滋病毒感染者 (PLWH) 死亡的重要原因.
加密球菌脑膜炎约占全球艾滋病毒相关死亡率的15%,撒哈拉以南非洲的负担很高.
加密球菌抗原阳性个体的高死亡率表明潜在的未被诊断的加密球菌病.

研究的目的:

在撒哈拉以南非洲的艾滋病毒感染者中绘制和合成有关加密球菌抗原感染的现有证据.
确定研究缺口,并为管理加密球菌抗原感染的未来干预提供信息.
将证据转化为在高艾滋病毒负担环境中改善患者结果的证据.

主要方法:

将使用Arksey和O'Malley的方法框架进行范围审查,该方法框架由Levac等人提出.
综合的文献搜索将涵盖多个数据库和灰色文献,从最初到2022年.
研究选和质量评估将由两名独立审查员使用既定的标准和工具进行.

主要成果:

该部分在审查完成后将被填写.
该审查将绘制撒哈拉以南非洲艾滋病毒感染人口中加密球菌抗原感染的当前证据格局.
关键发现将突出流行,诊断方法和管理策略.

结论:

综合当前的证据对于推动PLWH中加密球菌抗原感染的管理至关重要.
这一范围审查将为有针对性的研究和改进的临床干预提供基础.
研究结果将支持在撒哈拉以南非洲和类似环境中减少与加密球菌抗原感染相关的死亡率.

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