快速适应新型病原体通过疾病耐受性在野生歌鸟的快速适应
Amberleigh E Henschen1,2, Michal Vinkler3, Marissa M Langager4
1Department of Biological Sciences, University of Memphis; Memphis, Tennessee, United States of America.
PLoS pathogens
|June 9, 2023
概括
宿主动物可以迅速发展对新病原体的耐受性,在不影响病原体水平的情况下限制损害. 在面对细菌感染的家中观察到的这种适应,涉及有针对性的免疫反应,并对疾病传播有影响.
科学领域:
- 进化生物学是进化的生物学.
- 生态生态学 生态生态学
- 病原体动态 病原体动态
背景情况:
- 动物宿主通过耐药性或耐受性适应新出现的传染病.
- 疾病耐受性限制宿主损伤而不减少病原体复制.
- 宿主耐受性进化的速度和机制尚不清楚.
研究的目的:
- 调查宿主对新型病原体耐受性演变的速度.
- 识别疾病耐受性背后的生理机制.
- 通过病原体入侵梯度检查自然种群中的宿主适应.
主要方法:
- 研究了沿着Mycoplasma gallisepticum (MG) 侵袭梯度的天然房子 (Haemorhous mexicanus) 种群.
- 在不同 MG 暴露史的人群中比较病理和病原体负载.
- 分析基因表达数据以确定与耐受性相关的免疫反应机制.
主要成果:
- 在25年内证明了房子青对疾病耐受性的快速演变.
- 患有较长时间MG流行病的人群表现出较少的病理,但具有相似的病原体负载.
- 基因表达表明,针对性的早期免疫反应与耐受性相关.
结论:
- 宿主耐受性可以快速演变 (<25年),以应对新出现的传染病.
- 针对性免疫反应是进化耐受性的关键生理机制.
- 了解耐受性对于预测病原体传播和宿主-病原体共同演变至关重要.
更多相关视频
相关概念视频
Transduction
49
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
49
Special Features of Adaptive Immunity
910
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
910
Limits to Natural Selection
31.4K
Organisms that are well-adapted to their environment are more likely to survive and reproduce. However, natural selection does not lead to perfectly adapted organisms. Several factors constrain natural selection.
31.4K
Immune Response Against Viral Pathogens
833
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
833
Natural Selection and Adaptation
254
Natural selection, a fundamental concept in evolutionary biology, is the mechanism by which evolution is driven, favoring organisms that are best adapted to their environments. This process enhances their chances of survival and reproduction. Adaptation, a key outcome of this process, involves genetic modifications that optimize an organism's functionality under specific environmental challenges, such as extreme cold or thinner air at high altitudes.
Beyond physical adaptations,...
Beyond physical adaptations,...
254
Frequency-dependent Selection
22.1K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
22.1K


