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相关概念视频

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

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The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
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RNA Interference01:23

RNA Interference

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
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Types of RNA01:20

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Nucleic Acid Structure01:25

Nucleic Acid Structure

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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ABLNCPP:基于注意力机制的双向长期短期记忆用于非编码RNA编码潜力的预测.

Lei Deng1, Ying Jiang1, Xiaowen Hu1

  • 1School of Computer Science and Engineering, Central South University, Changsha 410018, China.

Journal of chemical information and modeling
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概括
此摘要是机器生成的。

研究人员开发了一种新的深度学习模型ABLNCPP,用于识别非编码RNA (ncRNA) 中的编码潜力. 这一进步有助于理解ncRNA在癌症中的作用,可能导致新的癌症治疗方法.

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科学领域:

  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学

背景情况:

  • 新出现的证据表明,非编码RNA (ncRNA) 可以编码/蛋白质.
  • 这些ncRNA衍生分子涉及至关重要的细胞过程,包括癌症进展和新陈代谢.
  • 准确识别ncRNAs中的编码潜力对于功能研究至关重要.

研究的目的:

  • 开发一种用于区分ncRNA转录中的编码潜力的计算方法.
  • 为弥补专门关注ncRNA编码潜力预测的研究差距.
  • 提供一个工具,帮助ncRNA功能研究和癌症发现.

主要方法:

  • 提出了一个基于注意力机制的双向长期短期记忆 (LSTM) 网络,命名为ABLNCPP.
  • 引入了一种新的非重叠三核酸嵌入 (NOLTE) 方法,以捕获ncRNA序列中的序列特征.
  • 根据现有最先进的模型对ABLNCPP进行了评估.

主要成果:

  • 与其他模型相比,ABLNCPP在预测ncRNA序列的编码潜力方面表现出卓越的性能.
  • 该NOLTE方法有效地保存了序列信息,提高了预测准确度.
  • 该模型成功克服了ncRNA编码潜力评估的先前局限性.

结论:

  • ABLNCPP是预测ncRNA编码潜力的有效工具.
  • 预计这种方法将对癌症研究和治疗开发做出重大贡献.
  • 开发的模型和数据公开可供进一步研究.