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玉米丝黄通过PI3K/AKT/NF-κB通路改善高尿血症

Xizhu Wang^1,2, Liu Dong^1,2, Yifei Dong^1,2

¹National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, P. R. China.

Journal of agricultural and food chemistry

|June 9, 2023

概括

玉米丝黄 (CSF) 通过抑制桑丁氧化酶 (XOD) 和减少炎症,有效降低尿酸 (UA) 水平. 这项研究揭示了CSF.

科学领域:

代谢性疾病研究研究.
对天然化合物的药理学研究.

背景情况:

超尿血症 (HUA) 是一种普遍的代谢障碍,与尿酸 (UA) 升高和死亡风险增加有关.
玉米丝黄素 (CSF) 正在研究其潜在的健康益处,特别是在代谢条件下.

研究的目的:

探索玉米丝黄素 (CSF) 对高尿素血 (HUA) 的保护作用.
阐明CSF作用的基本机制,重点关注亡和炎症途径.

主要方法:

网络药理学被用来识别关键的亡和炎症相关的信号通路.
实验室试验评估了CSF对丁氧化酶 (XOD) 和素酸转移酶水平的影响.
在体内研究中使用氧酸盐诱导的HUA模型来评估CSF的疗效.

主要成果:

在实验室中,CSF通过降低丁氧化酶 (XOD) 活性,表现出显著的尿酸降低活性.
在体内,脑脊液治疗抑制了XOD活性,促进了UA分泌,并减少了促炎标记物 (TNF-α,IL-6).
脊髓瘤治疗减轻了与HUA相关的病理损伤,并调节了PI3K/AKT/NF-κB通路.

结论:

玉米丝黄 (CSF) 显示出治疗超尿血症 (HUA) 的治疗潜力.
通过PI3K/AKT/NF-κB信号通路,CSF通过减少炎症和亡来改善HUA.
脑脊髓可以被认为是解决高尿血症的功能性食品成分.

关键词:

在PI3K/AKT/NF-κBB中.玉米丝的黄胺是玉米丝的黄胺.超血症是什么意思尿酸是什么尿酸是什么尿酸是什么亚丁氧化酶是一种亚丁氧化酶.

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