化学素是血管的常驻物,有助于血管调
Emma Wabel1, Alexis Orr1, Emma D Flood1
1Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United States.
概括
独立于肝脏的血管衍生的化学素,通过维持血管度来支持血压调节. 这一发现突出显示了化学素作为高血压的潜在治疗点.
科学领域:
- 心血管生理学心血管生理学
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
背景情况:
- 阿迪波金化学素会影响血压,但其来源和机制尚不清楚.
- 虽然肝脏是循环化学素的主要来源,但肝脏特异性抑制没有影响血压,这表明了其他来源.
- 人们假设血管系统可以独立于肝脏产生化学素,以调节动脉律.
研究的目的:
- 为了研究血管系是否独立于肝脏产生化学素.
- 确定血管衍生化学素在维持血管和血压方面的作用.
- 探索化学素及其受体Chemerin1作为血压调节的潜在治疗点.
主要方法:
- 使用的达尔盐敏感 (SS) 鼠 (雄性和雌性) 在正常饮食中.
- 采用了RNAScope,PCR,西部斑,反意义寡核酸 (ASOs),同位数收缩性和射电测量.
- 研究了大动脉组织中的化学素表达,并评估了在抑制化学素1受体时血管度的变化.
主要成果:
- 在各种血管层 (光滑肌肉,冒险,周围血管脂肪组织,内皮) 中检测到红丝酸受体响应者2 (Rarres2) mRNA和化学蛋白.
- 血管化学素水平不受肝脏特定的ASO或全球化学素淘汰的影响,这证实了其与肝脏生产的独立性.
- 抑制Chemerin1受体导致血管律的丧失,这表明Chemerin通过该受体在维持动脉律中的作用.
结论:
- 血管系统在局部合成化学素,独立于肝脏,有助于血管律.
- 血管衍生的化学素通过构成性激活化学素1受体在局部作用,以支持动脉律.
- 凯梅林代表了管理血压和相关心血管疾病的新型治疗标.
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