亚拉/亚格 (ALA/Ag) 是一种
Mahshid Hashemkhani1, Eda Celikbas2, Minahil Khan3
1Graduate School of Materials Science and Engineering, Koc University, Rumelifeneri Yolu, Sariyer, 34450 Istanbul, Turkey.
ACS biomaterials science & engineering
|June 9, 2023
概括
这项研究开发了结合光热疗法 (PTT) 和光动力疗法 (PDT) 的新型治疗纳米粒子 (NP),以克服瘤缺氧. 这些NP增强了活性氧物种 (ROS) 生成和ALA-PDT效率,在与PTT结合时显著改善了癌细胞死亡.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 光热疗法 (PTT) 和光动力疗法 (PDT) 提供局部瘤治疗,毒性最小.
- 5-氨基联氨酸 (ALA) 是一种流行的PDT前药物,但其疗效因瘤缺氧而受到限制.
- 纳米粒子 (NP) 可以增强药物输送和治疗结果.
研究的目的:
- 开发稳定,治疗性NP用于增强瘤的联合PDT/PTT.
- 为了克服瘤缺氧并提高ALA-PDT的效率.
- 提供可光学追踪的PTT和PDT代理.
主要方法:
- 用牛血清白蛋白 (BSA) 稳定并充满MnO2和ALA的Ag2S量子点 (AS QD) 的合成.
- 在激光照射后的NP稳定性,光学跟踪和温度增加的表征.
- 在联合激光照射下对细胞毒性,活性氧物种 (ROS) 生成和癌细胞活力的体外评估.
主要成果:
- 开发出稳定的,神经复杂的AS-BSA-MnO2NP,充满了ALA.
- 已证明NP对光学跟踪和PTT的能力 (在808nm时增加15°C).
- 通过联合PDT/PTT实现显著的癌细胞死亡 (5-10%活力),超过单个疗法,与高ROS水平相关.
结论:
- 混合NP有效地克服瘤缺氧,并为增强PDT/PTT提供ALA.
- 在短时间,低剂量联合照射后,治疗性NP提供NIR跟踪和强大的组合疗法.
- 这些NP对治疗各种癌症类型具有前途,需要进行体内研究.
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