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Updated: Jul 27, 2025

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells

Published on: October 16, 2018

在大B细胞淋巴瘤中使用CAR T细胞治疗

Alexander P Boardman¹, Gilles Salles¹

¹Memorial Sloan Kettering Cancer Center, Lymphoma Service, New York, New York, USA.

Hematological oncology

|June 9, 2023

概括

化学抗原受体 (CAR) 针对CD19的T细胞疗法已经改变了大型B细胞淋巴瘤 (LBCL) 治疗. 最近的数据显示,CAR-T细胞即使在具有挑战性的病例中也是有效的,包括中枢神经系统参与的病例.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
细胞疗法细胞疗法

背景情况:

针对CD19的仿真抗原受体 (CAR) T细胞已经显著推进了淋巴细胞恶性瘤治疗.
已批准的CAR T细胞疗法已建立用于大B细胞淋巴瘤 (LBCL) 的第三线治疗.

研究的目的:

为支持在LBCL患者中使用CAR T细胞的临床数据提供全面的概述.
突出CAR T细胞治疗在LBCL中的扩展应用,包括早期的治疗线和中枢神经系统参与.

主要方法:

对临床试验数据和关于LBCL中CD19-CART细胞治疗的出版文献的审查.
从早期阶段和后续研究中分析疗效和安全性数据.

主要成果:

CD19-CAR T细胞在LBCL中表现出革命性的疗效.
现在的研究支持二线使用和高风险患者在完成一线治疗之前进行治疗.
在初级和二级中枢神经系统淋巴瘤患者中观察到有前途的疗效.

结论:

CD19-CAR T细胞疗法代表了LBCL管理的重大突破.
对LBCL的治疗环境正在发展,CAR T细胞在更广泛的患者群体和早期治疗环境中显示出潜力.

关键词:

在B细胞淋巴瘤.CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 自体干细胞移植 (ASCT)嵌合式抗原受体 (CAR) T细胞扩散性大B细胞淋巴瘤 (DLBCL)非霍奇金淋巴瘤 (NHL) 是一种非霍奇金淋巴瘤.主要的中枢神经系统淋巴瘤 (PCNSL)二次性中枢神经系统淋巴瘤 (SCNSL)

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