常规的弹性质染色改善了结直肠癌中的静脉入侵检测
Hisham F Bahmad1, Ferial Alloush1, Ali Salami2
1Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA.
Annals of diagnostic pathology
|June 9, 2023
概括
常规的弹性质染色显著增加了结直肠癌样本中的静脉入侵检测. 这种方法增强了瘤扩散的识别,改善了转移性进展的诊断准确性.
科学领域:
- 病理学 病理学 病理学
- 在瘤学瘤学.
- 手术病理学手术病理学
背景情况:
- 结肠直肠癌是北美癌症死亡的主要原因.
- 瘤细胞侵入血液和淋巴血管对于结直肠癌转移至关重要.
研究的目的:
- 评估常规弹性质染色对大肠直肠癌 (CRC) 切除标本中的静脉入侵 (VI) 检测的影响.
- 为了比较VI检测率在实施标准化弹性染协议之前和之后.
主要方法:
- 采用了前后研究设计,比较了2021年 (实施前,n=93) 和2022年 (实施后,n=61) 的CRC标本.
- 在实施后的队列中,在所有可行的含瘤块上进行了常规弹性质染色.
- 临床病理学参数收集并分析了两个队列.
主要成果:
- 静脉侵袭检测显著增加,从实施前队列中的18.6%增加到实施后队列中的50.8%.
- 在单变量分析中,弹性染的实施与VI检测增加显著相关 (OR=4.5,p<0.001),在多变量分析中保持独立显著 (OR=2.6,p=0.034).
- 在该队列之间的其他临床病理学参数中没有发现显著差异.
结论:
- 在结直肠癌切除样本中,所有含瘤块的常规弹性质染色证实了静脉入侵检测率的增加.
- 这种增强的检测方法可以更好地识别结直肠癌转移的关键因素.
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