儿童并发症严重程度影响图雷特综合征患者青少年物质消费
Kaja Andersen1, Camilla Groth1, Liselotte Skov1
1Department of Pediatrics, National Tourette Syndrome Clinic, Herlev University Hospital, Herlev, Denmark.
Pediatric neurology
|June 9, 2023
概括
图雷特综合征 (TS) 和严重注意力缺陷/多动障碍 (ADHD) 的儿童面临更高的物质使用风险. 然而,强迫症 (OCD) 严重程度可能会对酒精,香烟和非法物质消费提供保护.
科学领域:
- 神经发育障碍 神经发育障碍
- 儿童和青少年精神病学
- 药物使用研究研究.
背景情况:
- 图雷特综合征 (TS) 经常与注意力缺陷/多动障碍 (ADHD) 和强迫症 (OCD) 一起发生.
- 了解这些疾病对儿科患者物质使用的长期影响至关重要.
研究的目的:
- 研究TS,ADHD,强迫症严重程度和社会经济地位之间的纵向关系.
- 确定它们对儿童TS患者物质使用模式的影响.
主要方法:
- 314名儿科TS患者的队列在基线 (T1) 评估TS,ADHD,强迫症严重程度和监护人的社会经济地位.
- 在T2的随访 (中位数为5.6年后) 涉及227名报告酒精,香烟和非法物质使用的患者.
- 二元逻辑回归分析了T1因素和T2物质使用之间的关联.
主要成果:
- 增加的ADHD严重程度和较低的社会经济地位预测了更高的香烟消费.
- ADHD的存在和严重程度与增加的非法物质使用有关.
- 强迫症的严重程度增加与香烟,非法物质和酒精消费的减少有关.
结论:
- 患有较高ADHD严重程度的儿科TS患者表现出青少年物质使用的风险较高.
- 强迫症的严重程度似乎是这种人群中对物质使用的保护因素.
- 建议针对性药物使用的预防性干预措施适用于严重ADHD的TS患者.
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