青春期不同预测男性和女性年轻人的大脑成熟:一个纵向的ABCD研究
Dani Beck1, Lia Ferschmann2, Niamh MacSweeney3
1Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway; NORMENT, Institute of Clinical Medicine, University of Oslo, Norway; PROMENTA Research Center, Department of Psychology, University of Oslo, Norway.
Developmental cognitive neuroscience
|June 9, 2023
概括
青春期的状态会影响青少年的大脑发育. 这项研究发现,青春期发育预测大脑结构的变化,在男性和女性之间观察到一些差异.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 儿科 儿科 儿科
背景情况:
- 现有的研究表明青春期与大脑成熟之间存在联系,但缺乏纵向数据和明确的方向性.
- 以前的研究受到小样本大小,横截面设计和关于性别差异的不确定的发现的限制.
研究的目的:
- 调查青春期发育和大脑结构成熟之间的纵向关系在儿童和青少年的大队伍中.
- 为了检查性差异在青春期状态和大脑发展随时间的推移之间的联系.
主要方法:
- 利用了青少年大脑和认知发展 (ABCD) 研究的数据,包括基线8896名参与者和随访6099名参与者.
- 采用多组多变的潜在变化得分 (BLCS) 模型来分析青春期状态 (青春期发育量表 - PDS) 和大脑结构 (MRI) 的时间合.
- 集成的扩散张力成像 (DTI) 来评估白质的完整性 (分数异构 - FA,平均扩散度 - MD).
主要成果:
- 基线青春期状态 (PDS) 预测了女性皮质厚度和两性皮质表面积变化率.
- 在男性中观察到基线PDS和表面积之间的相关性,以及随着时间的推移同时发生的变化.
- 在两种性别中,DTI显示了PDS和分数异构性 (FA) 之间的相关变化,但与平均扩散率 (MD) 没有显著的关联.
结论:
- 青春期的青春期状态是青春期皮质成熟的重要预测因素.
- 青春期发育和大脑结构变化之间的关系表现出性别特异的模式.
- 需要在整个青春期进行进一步的纵向研究,以充分阐明青春期大脑发育轨迹.
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