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多作用 (IV) 前药与抑制COX的NSAID结合

Xiao Liu1, Dominik Wenisch2, Philipp Dahlke3

  • 1Institute for Inorganic and Analytical Chemistry, Friedrich Schiller Universität Jena, Humboldt Str. 8, 07743, Jena, Germany.

European journal of medicinal chemistry
|June 9, 2023
PubMed
概括

结合化疗和非类固醇抗炎药物 (NSAID) 的新白金 (IV) 复合物显示出强大的抗癌活性. 综合体26与阿塞克洛芬雅克有效向癌细胞,并抑制炎症标志物.

关键词:
这是一种抗癌药物.细胞灭亡 (apoptosis) 是一种死亡的过程.循环氧基因酶的抑制.无抗炎药 (NSAIDs) 是一种无抗炎药.Pt(IV) 是一种前期药物.

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