AOP-helpFinder 2.0:集成一个事件-事件搜索模块
Thomas Jaylet1, Thibaut Coustillet1, Florence Jornod1
1Université Paris Cité, Inserm U1124, 45 rue des Saints Pères, 75006 Paris, France.
Environment international
|June 9, 2023
概括
更新的AOP-helpFinder工具通过自动选PubMed摘要来增强毒理学研究,以识别和优先考虑不利结果途径 (AOP) 发展的关键事件关系.
科学领域:
- 毒理学 毒理学 毒理学
- 计算生物学 计算生物学
- 监管科学 监管科学
背景情况:
- 不良结果途径 (AOPs) 对于监管化学品风险评估至关重要,它将分子启动事件与不良结果相结合.
- 开发AOP需要从各种来源进行广泛的数据挖掘,这对研究人员来说是一个重大挑战.
- 像AOP-helpFinder这样的现有工具有助于AOP开发,但需要提高效率和全面性.
研究的目的:
- 引入更新的AOP-helpFinder工具,提供新的功能,以改善AOP开发.
- 从毒理学文献中自动识别和提取事件-事件关联.
- 通过新的评分系统和可视化选项来增强AOP的优先级和可靠性评估.
主要方法:
- 实施了PubMed摘要的自动选,以识别和提取事件与事件的关联.
- 开发了一种新的评分系统,用于分类和优先考虑已识别的压力因素-事件和事件-事件关系.
- 集成的可视化选项,以促进对AOP数据和关系的解释.
主要成果:
- 更新后的AOP-helpFinder成功地选了PubMed摘要的事件-事件关联,简化了数据收集.
- 一个新的评分系统有助于优先考虑关键事件并评估AOP构建的证据的强度.
- 增强的可视化工具提高了复杂的AOP网络的理解和解释.
结论:
- 增强的AOP-helpFinder工具通过自动化文献分析和改进数据优先级,显著支持开发强大的AOP.
- 该工具有助于在监管毒理学中使用替代方法,促进数据驱动的风险评估.
- AOP-helpFinder的开源可用性和网页界面促进了在毒理学研究中更广泛的采用和合作.
关键词:
在 AOP AOP 中.在 AOP-helpFinder 的帮助下.负面结果的途径.人工智能的人工智能是人工智能.文本挖掘 (Text Mining) 是一种文字挖掘方式.毒理学 毒理学 毒理学更多相关视频
10:02Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
Published on: March 12, 2020
15.8K
09:52How to Find Effects of Stimulus Processing on Event Related Brain Potentials of Close Others when Hyperscanning Partners
Published on: May 31, 2018
7.8K
相关概念视频
Integration of Synaptic Events
1.6K
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
1.6K
Active Filters
864
Active filters are electronic circuits that use operational amplifiers (op-amps), resistors, and capacitors to filter out unwanted frequency components from a signal. A first-order low-pass active filter is designed to pass signals with a frequency lower than a certain cutoff frequency and attenuate frequencies higher than that cutoff frequency. The transfer function for a first-order low-pass active filter is:
864
Amines to Alkenes: Hofmann Elimination
2.6K
Alkenes can be obtained from amines via an E2 elimination. The amine is first converted into a good leaving group, such as a quaternary ammonium salt. This is accomplished by treating the amine with an excess of alkyl halide, which results in a halide salt. Next, the halide salt is transformed into a hydroxide salt that functions as a base to enable elimination.
Under thermal conditions, the hydroxide can abstract a proton from the β carbon; this generates an alkene with the simultaneous...
Under thermal conditions, the hydroxide can abstract a proton from the β carbon; this generates an alkene with the simultaneous...
2.6K
ER Retrieval Pathway
3.9K
In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
3.9K
Mass Analyzers: Overview
745
The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
745
Passive Filters
563
Passive filters are utilized to shape the frequency spectrum of signals across a diverse array of applications. These filters, using only passive elements like resistors (R), inductors (L), and capacitors (C), are capable of selectively allowing or blocking certain frequency ranges without the need for external power sources.
Low-Pass Filters
Low-pass filters are designed to transmit signals with frequencies lower than the cutoff frequency, ωc, and attenuate those above it. The cutoff...
Low-Pass Filters
Low-pass filters are designed to transmit signals with frequencies lower than the cutoff frequency, ωc, and attenuate those above it. The cutoff...
563
