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加快的金氨酸通路降低了轴性脊柱关节炎患者的免疫激活的调节

Emine Feyza Yurt¹, Cemile Biçer¹, Muhittin A Serdar²

¹Medical Biochemistry, Faculty of Medicine, Ankara Yıldırım Beyazıt University, Ankara, Türkiye.

|June 9, 2023

概括

在轴性脊椎关节炎 (axSpA) 患者中,金氨酸 (Kyn) 途径加速,可能限制免疫激活. 这项研究发现,尽管axSpA. axSpA中的英多莱胺 (2,3) - 二氧化酶 (IDO) 活性增加,但促炎性细胞因子的减少.

科学领域:

免疫学免疫学免疫学
生物化学生化学
类风湿病学类风湿病学

背景情况:

kynurenine (Kyn) 途径调节免疫系统的平衡.
促炎性细胞因子通过胺二氧化酶 (IDO) 影响Kyn通路活性.
免疫系统的调节失调与轴性脊椎关节炎 (axSpA) 的发病有关.

研究的目的:

调查Kyn途径,促炎细胞因子和axSpA.疾病严重程度之间的关系.
评估 axSpA 患者的 IDO 活性和 IL-17,IL-23 和 IFN-γ 的水平.

主要方法:

研究了104名axSpA患者和54名健康志愿者.
评估疾病严重程度使用浴化脊柱炎疾病活动指数 (BASDAI).
使用质谱和ELISA测量了IDO活性的血Kyn/Tryptophan (Trp) 比率和血清细胞因子水平 (IL-17,IL-23,IFN-γ).

主要成果:

与对照组相比,在axSpA患者中观察到血IOD活性增加.
在axSpA患者中发现IL-17,IL-23和IFN-γ的血清水平降低.
IFN-γ与疾病严重程度正相关,但与IDO活性相反;相关性很弱.

结论:

凯恩途径被加速,在axSpA中,促炎性细胞因子水平下降.
加速的Kyn通路活性可能会减弱axSpA.中的免疫系统激活.
IDO活动和疾病活动之间的弱逆相关性表明其具有复杂的监管作用.

关键词:

轴性脊椎关节炎是一种关节性关节炎.在IFN-γγ中.它们是IL-17/23的.印度莱胺 (2,3) 二氧化原酶基诺氨酸是什么基诺氨酸是什么 Kynurenine 三甲是什么?三甲是什么?

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