Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

5.1K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
5.1K
Antianginal Drugs: Nitrates and β-Blockers01:16

Antianginal Drugs: Nitrates and β-Blockers

664
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates,  such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
664
Antihypertensive Drugs: Vasodilators01:23

Antihypertensive Drugs: Vasodilators

581
Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
581
2° Amines to N-Nitrosamines: Reaction with NaNO201:20

2° Amines to N-Nitrosamines: Reaction with NaNO2

4.4K
Secondary amines react with nitrous acid to form N-nitrosamines, as depicted in Figure 1. Nitrous acid, a weak and unstable acid, is formed in situ from an aqueous solution of sodium nitrite and strong acids, such as hydrochloric acid or sulfuric acid, in cold conditions. In the presence of an acid, the nitrous acid gets protonated. The subsequent loss of water results in the formation of the electrophile known as nitrosonium ion.
4.4K
Paracrine Signaling01:21

Paracrine Signaling

55.2K
Paracrine signaling allows cells to communicate with their immediate neighbors via secretion of signaling molecules. Such a signal can only trigger a response in nearby target cells because the signal molecules degrade quickly or are inactivated if not taken up. Prominent examples of paracrine signaling include nitric oxide signaling in blood vessels, synaptic signaling of neurons, the blood clotting system, tissue repair/wound healing, and local allergic skin reactions. Nitric oxide as a...
55.2K
Nuclear Overhauser Enhancement (NOE)01:07

Nuclear Overhauser Enhancement (NOE)

757
Irradiation of a spin-active nucleus causes an increase or decrease in the signal intensity of neighboring nuclei that are not necessarily chemically bonded or involved in J-coupling.  This phenomenon, called the Nuclear Overhauser Enhancement (NOE), results from through-space interactions between the nuclear spins. The NOE effect decreases with increasing internuclear distance and is generally not observed beyond 4 angstroms. In NOE, dipole-dipole interactions between neighboring...
757

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Recent advances in nanomaterial-based strategies for chronic pain alleviation.

Materials today. Bio·2026
Same author

A synergistic nanozyme platform breaking the neuroinflammatory-oxidative stress cycle for extended pain relief.

International journal of pharmaceutics: X·2026
Same author

Combined effects of extreme heat and NO<sub>2</sub> on liver disease progression of T2DM mice.

Journal of hazardous materials·2026
Same author

Trait-Based Optimization of Plant Density in Drip-Fertigated Wheat: Yield Formation and Nitrogen-Radiation-Water Use Efficiency Responses of Varieties Contrasting in Individual Spike Productivity.

Plants (Basel, Switzerland)·2026
Same author

Prenatal 6:2 Cl-PFESA exposure and birth weight: A systematic review and meta-analysis.

Journal of hazardous materials·2026
Same author

Early-Life Ozone Exposure and Childhood Allergic Rhinitis: Critical Exposure Windows, Exposure-Response Relationships, and Protective Modifiers.

Environment & health (Washington, D.C.)·2026
Same journal

A hybrid data-driven machine learning method for mapping trace metals in urban soils: Integrating source apportionment to enable high accuracy prediction.

Journal of hazardous materials·2026
Same journal

Microwave co-pyrolysis of oily sludge and corn stalk under different microwave absorbents.

Journal of hazardous materials·2026
Same journal

Linking vegetation types to molecular signatures of dissolved organic matter and their distinct complexation mechanisms with cadmium.

Journal of hazardous materials·2026
Same journal

From legacy to emerging polycyclic aromatic compounds: Profiling in micro-nanoplastics emissions from plastic incineration.

Journal of hazardous materials·2026
Same journal

Molecular insights into sludge-derived organics transformation during magnetic Fe<sub>3</sub>O<sub>4</sub>-catalyzed wet air oxidation.

Journal of hazardous materials·2026
Same journal

Process-based interpretation of groundwater arsenic mobility via oxidative and reductive dissolution in a complex mine-waste system.

Journal of hazardous materials·2026
查看所有相关文章

相关实验视频

Updated: Jul 27, 2025

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
08:23

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

4.0K

NO 的作用 NO 的作用.

Chan Lu1, Faming Wang2, Qin Liu1

  • 1XiangYa School of Public Health, Central South University, Changsha 410078, China.

Journal of hazardous materials
|June 9, 2023
PubMed
概括
此摘要是机器生成的。

二氧化 (NO2) 暴露会通过增加呼吸道炎症,氧化应激和呼吸道过敏反应,使小鼠的过敏喘恶化. 这种污染物促进了喘的发展和易感性.

关键词:
呼吸道的炎症 呼吸道的炎症过敏性喘是一种过敏性喘.生物标志物生物标志物二氧化是二氧化的一种物质.氧化应激是一种氧化应激.

更多相关视频

Preparation of Rat Skeletal Muscle Homogenates for Nitrate and Nitrite Measurements
07:19

Preparation of Rat Skeletal Muscle Homogenates for Nitrate and Nitrite Measurements

Published on: July 29, 2021

2.4K
Application of Genetically Encoded Fluorescent Nitric Oxide (NO&#8226;) Probes, the geNOps, for Real-time Imaging of NO&#8226; Signals in Single Cells
08:32

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells

Published on: March 16, 2017

12.9K

相关实验视频

Last Updated: Jul 27, 2025

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
08:23

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

4.0K
Preparation of Rat Skeletal Muscle Homogenates for Nitrate and Nitrite Measurements
07:19

Preparation of Rat Skeletal Muscle Homogenates for Nitrate and Nitrite Measurements

Published on: July 29, 2021

2.4K
Application of Genetically Encoded Fluorescent Nitric Oxide (NO&#8226;) Probes, the geNOps, for Real-time Imaging of NO&#8226; Signals in Single Cells
08:32

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells

Published on: March 16, 2017

12.9K

科学领域:

  • 环境健康 环境健康
  • 毒理学 毒理学 毒理学
  • 免疫学 免疫学 免疫学

背景情况:

  • 二氧化 (NO2) 是一种常见的空气污染物,与喘发病率和死亡率的增加有关.
  • 在NO2对喘病原体产生影响的确切机制尚不清楚.

研究的目的:

  • 调查NO2暴露引起的过敏喘发展的毒理机制.
  • 在小鼠模型中阐明NO2如何影响呼吸道炎症,氧化应激和免疫反应.

主要方法:

  • 雄性Balb/c小鼠被分为四组:盐水控制,卵蛋白 (OVA) 敏感化,单独暴露于NO2,以及OVA+NO2.
  • 在30天的时间里,小鼠每天暴露在5ppm的NO2中,每天4小时.
  • 评估了肺炎,呼吸道重塑,呼吸道高反应 (AHR),细胞因子生产,免疫球蛋白E (IgE) 水平,Th1/Th2平衡和氧化应激标志物 (ROS,MDA,GSH).

主要成果:

  • 在喘小鼠中,NO2暴露加剧了肺炎和气道重塑,其特征是气道壁加厚和炎症细胞透.
  • NO2显著恶化了气道过敏反应 (AHR),增加了吸气和呼气阻力,同时降低了动态肺部顺应.
  • 促炎性细胞因子 (IL-6,TNF-α),血清IgE和氧化应激标志物 (ROS,MDA) 增加,而GSH水平下降. 观察到Th1/Th2不平衡 (增加IL-4,减少IFN-γ).

结论:

  • 暴露于NO2会加剧过敏性气道炎症,并增加小鼠的喘易感性.
  • 这些发现表明,NO2通过涉及炎症,氧化应激和Th1/Th2免疫失衡的机制,有助于喘发病.
  • 这项研究为NO2在过敏喘风险中的作用提供了毒理学证据.