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Updated: Jul 27, 2025

A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects TEdeff in Cancers
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在持续的药理抑制P-TEFb激酶活性后,Brd4依赖的CDK9表达诱导

Rongdiao Liu1

  • 1Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.

Biochemical and biophysical research communications
|June 9, 2023
PubMed
概括

抑制正转录延长因子b (P-TEFb) 活性会增加CDK9的表达,这一过程依赖于Brd4. 联合抑制Brd4和CDK9抑制了瘤细胞的生长,这表明了潜在的治疗策略.

关键词:
Brd4 的意思是 Brd4在CDK9中,CDK9是CDK9.表达的诱导感应表达的诱导.抑制抑制的抑制作用这就是P-TEFbb.转录延长 转录延长

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