青光眼治疗的新趋势:用拉坦普罗斯特加载的局部 osmoprotective 微乳液
J J López-Cano1, M A González-Cela-Casamayor1, V Andrés-Guerrero1
1Innovation, Therapy and Pharmaceutical Development in Ophthalmology (InnOftal) Research Group, UCM 920415, Department of Pharmaceutics and Food Technology, School of Pharmacy (UCM), Plaza Ramón y Cajal s/n, Madrid, 28040, Spain; Ocular Pathology National Net (OFTARED) of the Institute of Health Carlos III, Health Research Institute of the San Carlos Clinical Hospital (IdISSC), Madrid, 28040, Spain.
The ocular surface
|June 9, 2023
概括
装有拉坦普罗斯特的新型微乳液提供持续的眼睛表面保护,并降低眼内压力,用于治疗青光眼. 这些配方增强了药物的生物可用性,并改善了患者对有效的玻璃眼治疗的遵从性.
科学领域:
- 眼科医生 眼科 眼科
- 纳米技术 纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 长期使用低血压药物治疗青光眼可能会导致眼睛表面损伤,并降低患者的服从性.
- 需要新的持续药物输送系统来改善青光眼的管理和眼睛表面的健康.
研究的目的:
- 开发用于治疗青光眼的带有拉坦诺普罗斯特的保护性微乳液.
- 评估这些新型微乳液的眼睛表面保护性质和体内疗效.
主要方法:
- 微乳液的特征,包括滴滴大小和拉坦诺普罗斯特封装.
- 在体外评估细胞耐受性, osmoprotective 疗效和细胞微乳液相互作用.
- 在子模型中对低血压活性和眼部生物可用性的体内评估.
主要成果:
- 微乳液表现出纳米滴子大小 (20-30纳米) 和高的体外细胞活力 (80-100%).
- 配方表现出显著的 osmoprotective 效果和延长细胞光长达 11 天.
- 在体内研究显示,持续的眼内压力降低 (长达13天) 和明显更高的眼部生物可用性相比市场配方.
结论:
- 含有拉坦诺普罗斯特的微乳液有潜力作为双作用治疗青光眼的方法,既能保护眼睛表面,又能持续降低眼内压力.
- 这些微乳液代表了一种有前途的策略,以改善患者的遵从性和治疗结果在眼治疗.
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