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对过敏性疾病和环境的全表观基因组相关性研究

Andres Cardenas¹, Raj P Fadadu², Gerard H Koppelman³

¹Department of Epidemiology and Population Health, Stanford School of Medicine, Stanford University, Stanford, Calif.

The Journal of allergy and clinical immunology

|June 9, 2023

概括

全表观基因组关联研究 (EWAS) 揭示了与环境暴露和过敏疾病相关的DNA甲基化变化. 未来的研究应该整合环境因素,遗传学和多样化的人口来澄清因果关系并开发生物标志物.

科学领域:

环境表观遗传学环境表观遗传学
过敏和免疫学的过敏和免疫学.
人类遗传学人类遗传学

背景情况:

表观基因组,特别是DNA甲基化,弥合了环境影响,遗传构成和细胞反应.
DNA甲基化对环境暴露很敏感,并与过敏性疾病有关.
全表观基因组关联研究 (EWAS) 是调查这些关系的关键工具.

研究的目的:

审查和解释关于环境与过敏关系的EWAS的调查结果.
讨论这个研究领域的优势,挑战和未来的机会.
突出特定暴露和表观遗传变化之间的一致关联.

主要方法:

系统审查和解释已发表的EWAS调查结果.
专注于研究在产前和幼儿时期调查环境暴露的研究.
对白细胞和鼻细胞DNA的表观遗传变化的分析.

主要成果:

对于吸烟 (例如,AHRR基因) 和过敏性疾病 (例如,EPX基因) 等暴露,发现了一致的DNA甲基化关联.
欧洲环境学会 (EWAS) 已经确定了环境因素与与过敏相关的表观遗传修饰之间的联系.
研究主要利用白细胞分离的DNA,最近的研究包括鼻细胞.

结论:

建议进行长期前性研究,综合环境暴露和过敏结果,以确定因果关系.
未来的研究应该探索分区特定的表观遗传反应,遗传影响 (甲基化定量特征位置) 和多样化的种群.
从各种生物样本中仔细解释表观遗传特征至关重要.

关键词:

通过DNA甲基化.欧洲经济联盟 (EWAS) 的成员.过敏是一种过敏.喘喘是一种亚托巴亚托巴亚托巴亚亚多巴亚多巴亚多巴亚多巴亚多巴我们的环境环境环境环境环境环境环境环境表观遗传学是指表观遗传学.

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