固体植入装置用于持续药物输送
Elizabeth Magill1, Sara Demartis2, Elisabetta Gavini3
1School of Pharmacy, Queen's University Belfast, 97, Lisburn Road, Belfast BT9 7BL, UK.
Advanced drug delivery reviews
|June 9, 2023
概括
植入式药物输送系统 (IDDS) 提供持续的药物释放,克服口服和注射方法的局限性. 它们非常适合慢性疾病,使局部或全身输送能够改善患者的坚持和治疗结果.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送技术 药物输送技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 传统的药物管理 (口服,注射) 会导致血度的波动,需要频繁的剂量.
- 口服产生的挑战包括胃肠道降解和第一通代谢.
- 植入式药物输送系统 (IDDS) 为持续和可控的药物释放提供了一个解决方案.
研究的目的:
- 审查目前植入式药物输送系统 (IDDS) 的应用.
- 专注于IDDS制造中使用的材料.
- 突出应用IDDS的主要治疗领域.
主要方法:
- 对IDDS现有研究的文献综述.
- 在IDDS开发中使用的材料的分析.
- 根据治疗领域对IDDS应用进行分类.
主要成果:
- IDDS提供了长时间的药物输送,提高了治疗疗效.
- 用于IDDS的材料范围从聚合物到金属,适合特定的释放配置文件.
- 关键应用包括慢性疾病管理,疼痛控制和局部癌症治疗.
结论:
- 与传统的药物输送方法相比,IDDS是一个显著的进步.
- 材料选择对于优化IDDS性能和安全至关重要.
- IDDS提供了更好的患者遵从性和有针对性的药物输送,特别是在慢性疾病.
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