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相关概念视频

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

408
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
408
Drug Delivery: Overview01:16

Drug Delivery: Overview

329
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
329
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

526
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
526
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

645
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
645
Routes of Drug Administration: Enteral01:18

Routes of Drug Administration: Enteral

3.8K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
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相关实验视频

Updated: Jul 27, 2025

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.
12:17

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Published on: March 17, 2008

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固体植入装置用于持续药物输送.

Elizabeth Magill1, Sara Demartis2, Elisabetta Gavini3

  • 1School of Pharmacy, Queen's University Belfast, 97, Lisburn Road, Belfast BT9 7BL, UK.

Advanced drug delivery reviews
|June 9, 2023
PubMed
概括
此摘要是机器生成的。

植入式药物输送系统 (IDDS) 提供持续的药物释放,克服口服和注射方法的局限性. 它们非常适合慢性疾病,使局部或全身输送能够改善患者的坚持和治疗结果.

关键词:
可生物降解的聚合物.植入物植入物是一种植入物.当地的药物配送服务.持续的药物释放 持续的药物释放

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科学领域:

  • 生物材料科学 生物材料科学
  • 药物输送技术 药物输送技术
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 传统的药物管理 (口服,注射) 会导致血度的波动,需要频繁的剂量.
  • 口服产生的挑战包括胃肠道降解和第一通代谢.
  • 植入式药物输送系统 (IDDS) 为持续和可控的药物释放提供了一个解决方案.

研究的目的:

  • 审查目前植入式药物输送系统 (IDDS) 的应用.
  • 专注于IDDS制造中使用的材料.
  • 突出应用IDDS的主要治疗领域.

主要方法:

  • 对IDDS现有研究的文献综述.
  • 在IDDS开发中使用的材料的分析.
  • 根据治疗领域对IDDS应用进行分类.

主要成果:

  • IDDS提供了长时间的药物输送,提高了治疗疗效.
  • 用于IDDS的材料范围从聚合物到金属,适合特定的释放配置文件.
  • 关键应用包括慢性疾病管理,疼痛控制和局部癌症治疗.

结论:

  • 与传统的药物输送方法相比,IDDS是一个显著的进步.
  • 材料选择对于优化IDDS性能和安全至关重要.
  • IDDS提供了更好的患者遵从性和有针对性的药物输送,特别是在慢性疾病.