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相关概念视频

Nitric Oxide Signaling Pathway01:28

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Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
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Many receptor binding ligands are hydrophilic; they do not cross the cell membrane but bind to cell-surface receptors. Thus, their message must be relayed by second messengers present in the cell cytoplasm. There are several second messenger pathways, each with its own way of relaying information. For example, the G protein-coupled receptors can activate both phosphoinositol and cyclic AMP (cAMP) second messenger pathways. The phosphoinositol pathway is active when the receptor induces...
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Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high...
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Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
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Antihypertensive Drugs: Vasodilators01:23

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Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
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Inorganic Nitrogen Assimilation01:22

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Nitrogen is an essential element in biological systems, forming a crucial component of proteins, nucleic acids, and other cellular constituents. Many bacteria and archaea acquire nitrogen in the form of nitrate (NO₃⁻) or ammonia (NH₃), which are then assimilated into biomolecules through specific enzymatic pathways.Assimilatory Nitrate ReductionWhen nitrate enters the cell, it undergoes a two-step reduction process known as assimilatory nitrate reduction. Initially, the enzyme...
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Measurement of Cyclic Guanosine Monophosphate (cGMP) in Solid Tissues using Competitive Enzyme-Linked Immunosorbent Assay (ELISA)
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氧化循环GMP-K的氧化物.

Mohammad Amin Behmanesh1, Amin Rasekhian2, Forutan Kiani2

  • 1Department of Histology, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran.

Alcohol (Fayetteville, N.Y.)
|June 9, 2023
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概括

蒙特卢卡斯特是一种白血受体对抗剂,在老鼠中表现出对乙醇诱导的胃损伤的胃保护作用. 这种保护涉及氧化-循环瓜诺辛单酸盐-ATP敏感通道通路.

关键词:
NO-cGMP-K ((ATP) 道的使用情况.乙醇乙醇是一种胃口保护 胃口保护蒙特鲁卡斯塔尔是世界上最古老的鼠标 鼠标 鼠标 鼠标 鼠标

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科学领域:

  • 药理学 药理学是指药理学的学科.
  • 胃肠病学 胃肠病学
  • 细胞信号传输 细胞信号传输

背景情况:

  • 胰岛素是涉及乙醇诱导的胃损伤的脂质媒介.
  • 了解胃保护机制对于开发有效的治疗方法至关重要.

研究的目的:

  • 为了评估蒙特卢卡斯特的胃保护作用,一个白血受体对抗剂.
  • 为了研究氧化物 (NO) - 循环瓜诺辛单酸盐 (cGMP) - 敏感ATP通道 (KATP) 途径在蒙特卢卡斯特作用中的参与.

主要方法:

  • 在老鼠中以乙醇诱导的胃损伤模型.
  • 蒙特卢卡斯特单独或与调节NO-cGMP-KATP通路的药物 (l-arginine,l-NAME,甲蓝,西尔德纳菲尔,氧化物,glibenclamide) 结合使用.
  • 评估宏观,显微和促炎性细胞因子 (TNF-α,IL-1β) 的水平.

主要成果:

  • 蒙特卢卡斯特显著降低了乙醇诱导的胃病变 (宏观和微观) 和促炎性细胞因子水平.
  • 抑制氧化合成酶 (NOS),酸环酶或KATP通道减弱了蒙特卢卡斯特的保护作用.
  • 用NO前体,PDE-5抑制剂或KATP通道开启剂进行预处理,增强了胃保护.

结论:

  • 蒙特卢卡斯特在老鼠中表现出显著的胃保护作用,防止乙醇诱导的胃损伤.
  • 蒙特卢卡斯特的胃保护机制至少部分由NO-cGMP-KATP通道途径介导.