亚洲通过JAK/STAT3介导的炎症缓解牛皮:一个体外和体外研究
Pei Lin1, Hong-Yu Shi1, Yin-Ying Lu1
1School of Life Sciences and Health Engineering, Jiangnan University, Wuxi, 214122, China.
Journal of ethnopharmacology
|June 9, 2023
概括
Centella asiatica提取物有效地减少皮肤炎症,并改善牛皮模型中的屏障功能. 该研究强调了JAK/STAT3通路作为其治疗效果的关键机制,支持其在护肤中的使用.
科学领域:
- 植物化学 植物化学
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
背景情况:
- 亚洲 (CA) 传统上用于炎症性皮肤疾病.
- 牛皮是一种慢性炎症性皮肤病,治疗机制不完全理解.
- 在牛皮中CA的抗炎作用和特定机制需要进一步阐明.
研究的目的:
- 为了评估Centella asiatica提取物对炎症性皮肤病的疗效.
- 研究JAK/STAT3信号通路在CA对牛皮的治疗效果中的作用.
- 确定最有效的CA提取物及其作用机制.
主要方法:
- 提取和植物化学分析Centella asiatica的成分.
- 在体外评估对LPS诱导的HaCaT细胞的抗氧化,抗炎和皮肤屏障效应.
- 通过RT-PCR和西方涂抹对亡,NF-κB和JAK/STAT3通路激活的分析.
- 在体内评估CA提取物在因米基莫德诱导的牛皮类小鼠模型上的疗效.
主要成果:
- 亚洲的提取物表现出显著的抗氧化能力和减少氧化应激.
- 乙酸乙烯提取物 (CAE) 是最有效的,降低了炎症因素 (IFN-γ,CCL20,IL-6,TNF-α) 的调节,并改善了皮肤屏障基因 (AQP3,FLG).
- CAE抑制了NF-κB和JAK/STAT3通路,体内研究显示,CAE治疗小鼠的皮肤病变和炎症减少.
结论:
- 亚洲的提取物有效地减轻皮肤炎症和屏障功能障碍.
- JAK/STAT3信号通路是Centella asiatica在减轻牛皮的关键目标.
- 研究结果支持在功能性食品和护肤产品中使用亚洲菌治疗炎症性皮肤疾病.
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