LGTRL-DE:本地和全球时间代表性学习与人口嵌入,用于医院死亡率预测
Mengjie Zou1, Ying An2, Hulin Kuang1
1Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, Changsha, 410083, PR China.
Journal of biomedical informatics
|June 9, 2023
概括
这项研究引入了一个新的深度学习模型,LGTRL-DE,用于使用电子病历预测患者住院死亡率. 该模型有效地捕获时间数据和人口背景,优于现有方法.
科学领域:
- 医疗信息学 医疗信息学
- 医疗保健中的人工智能
- 临床决策支持 临床决策支持
背景情况:
- 从电子医疗记录 (EMR) 预测住院死亡率对于临床决策和资源分配至关重要.
- 现有的深度学习方法往往难以完全捕捉EMR数据中的时间动态和人口背景.
- 需要先进的模型,整合时间和静态患者信息,以准确预测死亡率.
研究的目的:
- 开发和评估一种新的端到端深度学习方法,即以人口嵌入的本地和全球时间代表性学习 (LGTRL-DE),用于预测住院死亡率.
- 改善从EMR中的人口信息中对时间表示和上下文知识的全面学习.
- 通过有效地融合时间和静态患者数据,提高住院死亡率预测的准确性.
主要方法:
- 拟议的LGTRL-DE模型具有局部时间表示学习模块 (具有人口初始化和局部注意力的RNN) 来分析健康状况.
- 整合了一个基于变压器的全球时间表示学习模块,以捕捉临床事件之间的相互作用.
- 使用多视图表示融合模块,将时间和静态信息集成为最终的患者健康表示.
主要成果:
- 在MIMIC-III数据集上,LGTRL-DE在接收器运行特征曲线 (AUC) 下的面积为0.8685.
- 该模型在e-ICU数据集上表现出强的性能,AUC为0.8733.3.
- 在医院死亡率预测方面,LGTRL-DE的表现优于现有的几种最先进的方法.
结论:
- 拟议的LGTRL-DE模型通过将本地和全球时间学习与人口嵌入相结合,有效地预测住院死亡率.
- 与当前方法相比,该方法表现出优越的性能,突出了其临床应用的潜力.
- 在利用EMR数据来准确预测患者的结果方面,LGTRL-DE提供了有前途的进展.
相关概念视频
Applications of Life Tables
94
Life tables are versatile across various fields, providing a quantitative basis for analyzing mortality and survival rates. Whether used by demographers, actuaries, epidemiologists, or sociologists, life tables offer valuable insights into the dynamics of life and death, facilitating informed decisions in public health, insurance, conservation, and beyond. Their broad applicability highlights the interconnectedness of demographic data with practical outcomes in everyday life and strategic...
94
Kaplan-Meier Approach
197
The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
197
Life Tables
135
A life table is a statistical tool that summarizes the mortality and survival patterns of a population, providing detailed insights into the likelihood of survival or death across different age intervals within a cohort. By organizing data on survival probabilities and mortality rates, life tables offer a clear snapshot of population dynamics over time. They are extensively used in demography, public health, actuarial science, and ecology to analyze life expectancy, design health interventions,...
135
Introduction To Survival Analysis
301
Survival analysis is a statistical method used to study time-to-event data, where the "event" might represent outcomes like death, disease relapse, system failure, or recovery. A unique feature of survival data is censoring, which occurs when the event of interest has not been observed for some individuals during the study period. This requires specialized techniques to handle incomplete data effectively.
The primary goal of survival analysis is to estimate survival time—the time...
The primary goal of survival analysis is to estimate survival time—the time...
301
Actuarial Approach
101
The actuarial approach, a statistical method originally developed for life insurance risk assessment, is widely used to calculate survival rates in clinical and population studies. This method accounts for participants lost to follow-up or those who die from causes unrelated to the study, ensuring a more accurate representation of survival probabilities.
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
101
Prediction Intervals
2.3K
The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
2.3K


