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乙氨基酸能保护人免受肥胖引起的代谢变化
Marina Chaves de Oliveira1, Ana Letícia Malheiros Silveira1, Amanda Carla Clemente de Oliveira1
1Immunometabolism, Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Immunopharmacology, Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Metabolism: clinical and experimental
|June 9, 2023
概括
乙氨基酸在维持新陈代谢平衡和脂肪组织健康方面发挥着至关重要的作用. 它们的存在影响葡萄糖代谢和炎症,影响肥胖和胰岛素敏感性,在小鼠和人类.
科学领域:
- 代谢研究的研究.
- 免疫学 免疫学 免疫学
- 肥胖研究的研究.
背景情况:
- 氨基酸通常与寄生虫感染和过敏有关.
- 它们在代谢变化和脂肪组织重塑中的作用主要是通过动物肥胖模型来研究.
- 氨酸在新陈代谢调节中的精确生理功能仍未得到充分研究.
研究的目的:
- 为了研究埃索诺菲尔在代谢和脂肪组织恒温的参与.
- 在小鼠和人类中探索乙氨基基基功能的翻译相关性.
- 了解埃索诺菲尔如何调节葡萄糖代谢,炎症和脂肪积累.
主要方法:
- 使用了野生类型 (WT) 和GATA-1淘汰赛 (Δdb/GATA-1-/-) 的小鼠.
- 对小鼠进行定期的高碳水化合物 (HC) 或高脂肪 (HF) 饮食.
- 在肥胖的人群中分析了临床参数和全身脂肪组织 (AT) 基因表达.
主要成果:
- 在正常饮食的小鼠中,乙氨基酸缺乏导致胰岛素耐药性和脂肪增加.
- 缺乏乙氨基酸的小鼠的脂肪组织表现出较高的细胞因子水平和增加的白细胞透.
- 骨髓移植在接受者小鼠中部分恢复了葡萄糖代谢,并减少了脂肪质量.
- 饮食挑战加剧了小鼠的脂肪和葡萄糖功能障碍,特别是在HF饮食中.
- 在患有严重肥胖的人群中,乙氨基酸标记表达与炎症标记物和胰岛素敏感性指标相关联.
结论:
- 埃索诺菲尔似乎调节了全身和脂肪组织的新陈代谢平衡.
- 它们调节葡萄糖代谢,炎症和内脏脂肪扩张,即使在瘦人身上也是如此.
- 乙素也会影响人类肥胖症中的葡萄糖恒温.
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