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Updated: Jul 27, 2025

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
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有氧/力量训练对RANKL基因DNA甲基化水平的影响

Ameni Chelly1,2, Amal Bouzid1,3, Fadoua Neifar1

  • 1Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, University of Sfax, Sfax,Tunisia.

Journal of physical activity & health
|June 9, 2023
PubMed
概括

身体活动显著增加RANKL促进区的DNA甲基化,这是骨重塑的关键因素. 运动可以通过改变这些表观遗传变化来降低骨质疏松症的风险.

关键词:
进行有氧训练是有氧训练.表观遗传学是指表观遗传学.骨质疏松症是一种骨质疏松症.身体炼就是体力炼.

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Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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