雷梅西维尔在COVID-19治疗中的临床使用:回顾性队列研究
Hong Tham Pham1, Tuong-Anh Mai-Phan2,3, Anh Kiet Vu3
1Department of Pharmacy, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam.
BMJ open
|June 9, 2023
概括
雷梅西维尔在越南的COVID-19患者中降低了严重疾病和死亡率. 这种抗病毒药物还降低了对机械通风的需求,在资源有限的环境中提供了好处.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 在中低收入国家,COVID-19治疗的有效性仍未得到充分研究.
- 像remdesivir这样的抗病毒疗法对于管理COVID-19至关重要,但它们在各种环境中的实际影响需要评估.
研究的目的:
- 为了评估remdesivir在亚洲中低收入环境中的临床有效性.
- 提供关于remdesivir对COVID-19患者关键进展和资源利用的影响的直接证据.
主要方法:
- 一个回顾性队列研究,利用倾向性得分匹配.
- 310名接受标准护理 (SoC) 的患者与310名接受SoC+remdesivir (SoC+R) 的患者进行匹配.
- 主要结局:至危急进展的时间 (死亡率或危急疾病). 二次结果:氧气/通风的持续时间和需要侵入性机械通风.
主要成果:
- 雷梅西维尔显著降低了死亡或严重疾病的风险 (HR=0.68,p=0.030).
- 在SoC+R组 (OR=0.57,p=0.007) 中,侵入性机械通风的需要明显较低.
- 雷梅西维尔并没有显著缩短氧气治疗/通风的时间 (p=0.774).
结论:
- 雷梅西维尔在亚洲中低收入地区的非危急COVID-19患者中显示出临床益处.
- 研究结果支持在资源有限的地区使用remdesivir,可能改善结果并减少全球健康不平等.
- 该研究提供了证据,证明在资源有限的地区扩大治疗选择.
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