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集成部位依赖的HIV-1促进体活性塑造了宿主染色体的形状

Jack A Collora1, Ya-Chi Ho1

  • 1Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06519, USA jacollora@gmail.com ya-chi.ho@yale.edu.

Genome research
|June 9, 2023
PubMed
概括

人类免疫缺陷病毒1型 (HIV-1) 整合通过作为异位增强剂来增强宿主染色体的可访问性和基因表达. 这种整合影响了局部染色质结构,并与远程宿主DNA相互作用,由特定的转录因子介导.

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