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Updated: Jul 27, 2025

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麻醉诱导的神经毒性的临床前证据

Tom Bleeser1, Arjen Brenders1, Talia Rose Hubble2

  • 1Department of Anaesthesiology, UZ Leuven, Department of Cardiovascular Sciences, Group Biomedical Sciences, KU Leuven, Leuven, Belgium.

Best practice & research. Clinical anaesthesiology
|June 9, 2023
PubMed
概括

临床前研究表明,全身麻醉剂可能会损害年轻的大脑,导致神经元损伤和神经行为缺陷. 这些效应会随着重复,长时间或高剂量麻醉暴露而恶化.

关键词:
麻醉引起的神经毒性动物模型动物模型产科麻醉 产科麻醉儿科麻醉 儿科麻醉临床前研究 临床前研究

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Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
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