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在基于线性加速器的中子捕获疗法系统中,与固态目标相结合的基于线性加速器的中子捕获疗法系统中,热中子束被快速中子污染的相对生物有效性

Satoshi Nakamura^1,2,3, Shoji Imamichi^2,4,5, Kenzi Shimada⁶

¹Division of Radiation Safety and Quality Assurance, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Journal of radiation research

|June 9, 2023

概括

这项研究量化了中子束对中子捕获疗法 (BNCT) 的相对生物有效性 (RBE). 平均RBE为1.9,表明其在癌症治疗中的潜力.

科学领域:

医学物理医学物理
放射生物学的放射生物学
癌症治疗治疗癌症治疗

背景情况:

中子捕获疗法 (BNCT) 是一种先进的癌症治疗方式.
基于加速器的BNCT系统需要精确的中子束特征,以有效的剂量传递.
量化相对生物有效性 (RBE) 对于优化BNCT协议至关重要.

研究的目的:

为了确定被快速中子污染的高热中子束的RBE.
为了评估基于加速器的新型BNCT系统的生物有效性,使用固态目标.
为了比较中子束的RBE与各种癌症细胞系的X射线辐射.

主要方法:

实验是在东京国家癌症中心医院 (NCCH) 进行的.
四个细胞系 (SAS,SCCVII,U87-MG,NB1RGB) 用BNCT系统和医疗线性加速器 (LINAC) 作为参考进行了辐射.
使用LQ模型计算10%细胞存活分数 (D10) 的剂量,减去马射线贡献.

主要成果:

中子束的D10值在细胞系中从2.72 Gy到5.81 Gy不等.
对X射线辐射的D10值在5.49 Gy到7.21 Gy之间.
中子束计算的RBE值在1.3到2.5之间,平均RBE值为1.9.

结论:

基于加速器的BNCT系统产生了一个带热中子束,具有可量化的RBE.
平均RBE值为1.9,表明该系统在BNCT应用中的潜在有效性.
需要进一步的研究来优化治疗规划和临床翻译.

关键词:

基于加速器的BNCT系统子中子捕获疗法 (BNCT) 是一种治疗方法.中子束的中子束.相对生物有效性 (RBE)固态Li目标是固态Li的目标.

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