长期混合坚果消费改善大脑血管功能和记忆:老年人随机对照交叉试验
Kevin M R Nijssen1, Ronald P Mensink1, Jogchum Plat1
1Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands.
Clinical nutrition (Edinburgh, Scotland)
|June 9, 2023
概括
每日混合坚果消费改善了老年人大脑血管功能和记忆力. 这种饮食干预改善了大脑血液流动和认知表现,这表明坚果具有神经保护作用.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 老年学是一门学科.
背景情况:
- 与年龄相关的认知能力下降是一个日益关注的问题.
- 坚果消费可以缓解认知衰退的机制尚未完全理解.
- 脑血管功能是连接饮食和认知的潜在途径.
研究的目的:
- 为了检查混合坚果消费对老年人大脑血管功能的长期影响.
- 为了确定是否改善的血管功能与认知性能变化相关.
- 研究坚果对内皮功能,动脉硬和视网膜微血管结构的影响.
主要方法:
- 一个随机,单盲,交叉试验,涉及28名健康的老年人 (65±3岁).
- 参与者每天摄入60克混合坚果 (核桃, pistachios,果仁,子) 或控制 (没有坚果) 16周,有8周的洗期.
- 使用动脉旋转标记MRI评估大脑血管功能以测量大脑血流 (CBF);内皮功能,动脉硬性和视网膜微血管也被评估. 用剑桥神经心理测试自动化电池测量认知表现.
主要成果:
- 混合坚果消费显著增加了多个大脑区域的区域CBF,包括额叶和额叶叶.
- 在动脉反应性,手臂流介导血管扩张和视网膜动脉口径方面观察到改善.
- 视觉空间和语言记忆得分有所改善,而执行功能和精神运动速度保持不变.
结论:
- 长期消费混合坚果,作为健康饮食的一部分,对老年人大脑血管功能产生积极影响.
- 这些血管改善可能是记忆功能观察到的益处的基础.
- 该研究还表明,对外围血管标志物有有益影响.
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