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Updated: Jul 27, 2025

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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
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甲状腺自身免疫对甲状腺自身免疫对甲状腺自身免疫对甲状腺自身自身免疫对甲状腺自身自身免疫对甲状腺自身自身免疫对甲状腺自身自身免疫对甲状腺自身自身免疫对甲状腺自身自身免疫对甲状腺自身自身免疫对甲状腺自身自身免疫对甲状腺自身自身免疫对甲状腺
Ling Guo1, Xiyao Wang1, Yufeng Wang1
1Center for Reproductive Medicine, Shandong University, Jinan, Shandong, China; Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, China; Medical Integration and Practice Center, Shandong University, Jinan, Shandong, China.
Reproductive biomedicine online
|June 9, 2023
概括
甲状腺自身免疫 (TAI) 并没有显著影响大多数怀孕结果,在经过IVF/ICSI的反复植入失败 (RIF) 的甲状腺患者中. 然而,TAI与较低的生化妊娠率有关,这需要谨慎的临床方法.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 免疫学 免疫学 免疫学
- 在体外受精中进行体外受精.
背景情况:
- 复发性植入失败 (RIF) 影响了许多IVF/ICSI周期.
- 甲状腺自身免疫 (TAI) 在正常甲状腺功能的RIF患者中的作用尚不清楚.
- 了解TAI的影响对于优化试管婴儿/ICSI结果至关重要.
研究的目的:
- 为了调查甲状腺自身免疫 (TAI) 是否会对经过IVF/ICSI的甲状腺患者的妊娠结果产生不良影响,这些患者有复发性植入失败 (RIF).
- 为了比较TAI阳性和TAI阴性RIF患者之间的怀孕和新生儿结局.
- 确定潜在的混因素及其对TAI和IVF/ICSI成功之间的关系的影响.
主要方法:
- 对1031名接受试管婴儿/ICSI.RIF患者进行了回顾性队列研究.
- 根据血清自身抗体度,分为TAI阳性 (n=219) 和TAI阴性 (n=812) 组.
- 进行了后勤回归分析,子组和分层分析,以调整混因素并评估结果.
主要成果:
- 卵巢储备,反应,胚胎质量或大多数怀孕/新生儿结局在TAI阳性和TAI阴性组之间没有显著差异.
- 在对混杂因素进行调整后,TAI阳性患者的生化妊娠率显著降低 (OR 1.394,P=0.036).
- 在植入,临床怀孕,流产,死产或活产率方面没有发现显著差异,即使在亚组分析中也是如此.
结论:
- 甲状腺自身免疫 (TAI) 似乎不会对经过试管婴儿/ICSI的甲状腺外发性RIF患者的整体妊娠结果产生不利影响.
- 在TAI阳性患者中观察到较低的生化怀孕率,这表明有细微的效应.
- 针对该患者群体的TAI临床干预应谨慎进行,需要进一步的支持性证据.
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